DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1149:1155

E3 ligase: FBXW7

DEGRON score: 0.697

ASA_SCORE: 92.2429

COIL: 0.9659

CONS_SCORE: 0.2786

DSS_SCORE: 0.7926

HELIX: 0.0119

FCONS_SCORE: 0.9561

RIG_SCORE: 0.5421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1140P	DO227499	LAML	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.0833
p.P1145L	DO22851	LIHC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.S1158F	DO37432	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.25
p.A1148V	DO50287	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.P1157L	DO50288	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1149L	DO51234	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.6471
p.P1145S	DO38123	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1159S	ACH-002256	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1159S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons