DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1919:1926

E3 ligase: FBXW7

DEGRON score: 0.9656

ASA_SCORE: 102.4875

COIL: 0.9513

CONS_SCORE: 0.3143

DSS_SCORE: 0.7055

HELIX: 0.0091

FCONS_SCORE: 0.8733

RIG_SCORE: 0.7132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1925M	TCGA-A4-A57E	KIRP	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.6312
p.P1916S	TCGA-D3-A3MU	SKCM	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.P1916S	DO47337	SKCM	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.T1926I	TCGA-EY-A215	UCEC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.7078
p.G1923S	TCGA-F4-6570	COAD	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.6993
p.R1922C	TCGA-GN-A8LK	SKCM	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.8301
p.R1922C	ACH-001566	Skin Cancer	CCLE	PTTTPITT	DEG_SCF_FBW7_1	0.8301
p.S1915F	ACH-000491	Colon/Colorectal Cancer	CCLE	PTTTPITT	DEG_SCF_FBW7_1	0.2222
p.T1919I	ACH-000998	Colon/Colorectal Cancer	CCLE	PTTTPITT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1919:1926	PTTTPITT	FBXW7	0.9656	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1942:1949	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1965:1972	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1988:1995	PTTTPITT	FBXW7	0.9975	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2011:2018	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2034:2041	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2057:2064	PTTTPITT	FBXW7	0.9948	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2080:2087	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2103:2110	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2126:2133	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2149:2156	PTTTPITT	FBXW7	0.9452	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2172:2179	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2195:2202	PTTTPITT	FBXW7	0.9741	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2218:2225	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2241:2248	PTTTPITT	FBXW7	0.9973	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2264:2271	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2287:2294	PTTTPITT	FBXW7	0.9728	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2310:2317	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2333:2340	PTTTPITT	FBXW7	0.9467	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2356:2363	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2379:2386	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2402:2409	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2425:2432	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2448:2455	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2471:2478	PTTTPITT	FBXW7	0.968	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2494:2501	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2517:2524	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2540:2547	PTTTPITT	FBXW7	0.9767	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2563:2570	PTTTPITT	FBXW7	0.997	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2586:2593	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2609:2616	PTTTPITT	FBXW7	0.9784	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2632:2639	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2655:2662	PTTTPITT	FBXW7	0.9644	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2678:2685	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2701:2708	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2724:2731	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2747:2754	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2770:2777	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2793:2800	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2816:2823	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2839:2846	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2862:2869	PTTTPITT	FBXW7	0.9866	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2885:2892	PTTTPITT	FBXW7	0.9644	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2908:2915	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2931:2938	PTTTPITT	FBXW7	0.9302	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2954:2961	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2977:2984	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3000:3007	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3023:3030	PTTTPITT	FBXW7	0.9782	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3046:3053	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3069:3076	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3092:3099	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3115:3122	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3138:3145	PTTTPITT	FBXW7	0.9954	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3161:3168	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3184:3191	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3207:3214	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3230:3237	PTTTPITT	FBXW7	0.9665	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3253:3260	PTTTPITT	FBXW7	0.9785	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3276:3283	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3299:3306	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3322:3329	PTTTPITT	FBXW7	0.9812	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3345:3352	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3368:3375	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3391:3398	PTTTPITT	FBXW7	0.9728	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3414:3421	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3437:3444	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3460:3467	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3483:3490	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3506:3513	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3529:3536	PTTTPITT	FBXW7	0.9665	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3552:3559	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3575:3582	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3598:3605	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3621:3628	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3644:3651	PTTTPITT	FBXW7	0.9812	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3667:3674	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3690:3697	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3713:3720	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3736:3743	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3759:3766	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3782:3789	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3805:3812	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3828:3835	PTTTPITT	FBXW7	0.9878	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3851:3858	PTTTPITT	FBXW7	0.9524	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3874:3881	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3897:3904	PTTTPITT	FBXW7	0.9988	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3920:3927	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3943:3950	PTTTPITT	FBXW7	0.9968	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3966:3973	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3989:3996	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4012:4019	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4035:4042	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4058:4065	PTTTPITT	FBXW7	0.9988	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4081:4088	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4104:4111	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4127:4134	PTTTPITT	FBXW7	0.9704	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4150:4157	PTTTPITT	FBXW7	0.997	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4173:4180	PTTTPITT	FBXW7	0.9539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTPITT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of PTTTPITT