DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 2563:2570

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 106.0875

COIL: 0.9579

CONS_SCORE: 0.377

DSS_SCORE: 0.6965

HELIX: 0.0085

FCONS_SCORE: 1.1282

RIG_SCORE: 0.7134

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2566N	TCGA-E2-A14R	BRCA	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.7423
p.H2566N	DO3822	BRCA	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.7423
p.G2567E	TCGA-RP-A693	SKCM	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.7199
p.G2567E	DO51268	SKCM	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.7199
p.A2569V	ACH-000975	Lung Cancer	CCLE	PTTTPITT	DEG_SCF_FBW7_1	0.6936
p.G2562E	TCGA-90-A4ED	LUSC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.3056
p.G2562E	DO45482	LUSC	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.3056
p.K2561N	TCGA-G9-6329	PRAD	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.2778
p.K2561N	DO36281	PRAD	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.2778
p.E2559K	DO232869	PBCA	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.2222

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Drug responses associated with MUC2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTTTPITT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1919:1926	PTTTPITT	FBXW7	0.9656	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1942:1949	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1965:1972	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1988:1995	PTTTPITT	FBXW7	0.9975	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2011:2018	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2034:2041	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2057:2064	PTTTPITT	FBXW7	0.9948	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2080:2087	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2103:2110	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2126:2133	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2149:2156	PTTTPITT	FBXW7	0.9452	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2172:2179	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2195:2202	PTTTPITT	FBXW7	0.9741	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2218:2225	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2241:2248	PTTTPITT	FBXW7	0.9973	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2264:2271	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2287:2294	PTTTPITT	FBXW7	0.9728	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2310:2317	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2333:2340	PTTTPITT	FBXW7	0.9467	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2356:2363	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2379:2386	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2402:2409	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2425:2432	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2448:2455	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2471:2478	PTTTPITT	FBXW7	0.968	More...

Showing 1 to 25 of 99 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTPITT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of PTTTPITT