Degron: PTTTPITT
Mucin-2
MUC2
2172:2179
FBXW7
0.9803
98.8375
0.9576
0.2916
0.6965
0.0119
0.9964
0.7134
Degron related mutations and impact score
Mutation |
Sample |
Cancer |
Dataset |
Degron |
Degron class |
Impact score |
p.E2182K | TCGA-06-5416 | GBM | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.25 |
p.D2169N | TCGA-AP-A0LM | UCEC | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.25 |
p.V2179M | TCGA-AX-A1CE | UCEC | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.7208 |
p.V2179M | TCGA-VQ-A8PP | STAD | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.7208 |
p.K2170N | TCGA-BF-A1PU | SKCM | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.2778 |
p.R2175H | TCGA-BR-4361 | STAD | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.8244 |
p.R2175H | TCGA-EO-A22U | UCEC | TCGA | PTTTPITT | DEG_SCF_FBW7_1 | 0.8244 |
p.R2175H | ACH-001127 | Leukemia | CCLE | PTTTPITT | DEG_SCF_FBW7_1 | 0.8244 |
p.I2178T | ACH-002148 | Thyroid Cancer | CCLE | PTTTPITT | DEG_SCF_FBW7_1 | 0.7078 |
p.S2172F | ACH-002309 | Sarcoma | CCLE | PTTTPITT | DEG_SCF_FBW7_1 | 0.7982 |
Drug responses associated with MUC2 mutations
Sample |
Cancer |
Mutation (In Degron?) |
Dataset |
Drug |
IC50 |
All proteins holding degron of PTTTPITT