DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 2264:2271

E3 ligase: FBXW7

DEGRON score: 0.9803

ASA_SCORE: 104.7625

COIL: 0.9591

CONS_SCORE: 0.3634

DSS_SCORE: 0.6965

HELIX: 0.009

FCONS_SCORE: 0.9979

RIG_SCORE: 0.7134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2273V	TCGA-77-7141	LUSC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.2778
p.L2273V	DO26450	LUSC	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.2778
p.P2274R	TCGA-B4-5832	KIRC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.P2274R	DO17236	KIRC	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.P2274H	TCGA-D1-A17H	UCEC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.P2274H	DO41847	UCEC	ICGC	PTTTPITT	DEG_SCF_FBW7_1	0.25
p.T2266I	TCGA-D3-A8GI	SKCM	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.5966
p.D2270N	TCGA-DF-A2KU	UCEC	TCGA	PTTTPITT	DEG_SCF_FBW7_1	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTPITT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of PTTTPITT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1919:1926	PTTTPITT	FBXW7	0.9656	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1942:1949	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1965:1972	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1988:1995	PTTTPITT	FBXW7	0.9975	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2011:2018	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2034:2041	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2057:2064	PTTTPITT	FBXW7	0.9948	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2080:2087	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2103:2110	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2126:2133	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2149:2156	PTTTPITT	FBXW7	0.9452	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2172:2179	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2195:2202	PTTTPITT	FBXW7	0.9741	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2218:2225	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2241:2248	PTTTPITT	FBXW7	0.9973	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2264:2271	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2287:2294	PTTTPITT	FBXW7	0.9728	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2310:2317	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2333:2340	PTTTPITT	FBXW7	0.9467	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2356:2363	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2379:2386	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2402:2409	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2425:2432	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2448:2455	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2471:2478	PTTTPITT	FBXW7	0.968	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2494:2501	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2517:2524	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2540:2547	PTTTPITT	FBXW7	0.9767	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2563:2570	PTTTPITT	FBXW7	0.997	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2586:2593	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2609:2616	PTTTPITT	FBXW7	0.9784	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2632:2639	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2655:2662	PTTTPITT	FBXW7	0.9644	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2678:2685	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2701:2708	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2724:2731	PTTTPITT	FBXW7	0.9718	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2747:2754	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2770:2777	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2793:2800	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2816:2823	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2839:2846	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2862:2869	PTTTPITT	FBXW7	0.9866	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2885:2892	PTTTPITT	FBXW7	0.9644	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2908:2915	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2931:2938	PTTTPITT	FBXW7	0.9302	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2954:2961	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2977:2984	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3000:3007	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3023:3030	PTTTPITT	FBXW7	0.9782	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3046:3053	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3069:3076	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3092:3099	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3115:3122	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3138:3145	PTTTPITT	FBXW7	0.9954	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3161:3168	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3184:3191	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3207:3214	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3230:3237	PTTTPITT	FBXW7	0.9665	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3253:3260	PTTTPITT	FBXW7	0.9785	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3276:3283	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3299:3306	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3322:3329	PTTTPITT	FBXW7	0.9812	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3345:3352	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3368:3375	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3391:3398	PTTTPITT	FBXW7	0.9728	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3414:3421	PTTTPITT	FBXW7	0.9708	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3437:3444	PTTTPITT	FBXW7	0.9739	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3460:3467	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3483:3490	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3506:3513	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3529:3536	PTTTPITT	FBXW7	0.9665	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3552:3559	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3575:3582	PTTTPITT	FBXW7	0.9803	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3598:3605	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3621:3628	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3644:3651	PTTTPITT	FBXW7	0.9812	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3667:3674	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3690:3697	PTTTPITT	FBXW7	0.9724	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3713:3720	PTTTPITT	FBXW7	0.9857	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3736:3743	PTTTPITT	FBXW7	0.9858	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3759:3766	PTTTPITT	FBXW7	0.9701	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3782:3789	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3805:3812	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3828:3835	PTTTPITT	FBXW7	0.9878	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3851:3858	PTTTPITT	FBXW7	0.9524	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3874:3881	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3897:3904	PTTTPITT	FBXW7	0.9988	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3920:3927	PTTTPITT	FBXW7	0.9646	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3943:3950	PTTTPITT	FBXW7	0.9968	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3966:3973	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3989:3996	PTTTPITT	FBXW7	0.9694	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4012:4019	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4035:4042	PTTTPITT	FBXW7	0.98	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4058:4065	PTTTPITT	FBXW7	0.9988	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4081:4088	PTTTPITT	FBXW7	0.9972	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4104:4111	PTTTPITT	FBXW7	0.9814	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4127:4134	PTTTPITT	FBXW7	0.9704	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4150:4157	PTTTPITT	FBXW7	0.997	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4173:4180	PTTTPITT	FBXW7	0.9539	More...