| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JVU1 |
| Entrez ID | 362800 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_006240697.3 |
| Ensembl protein ID | ENSRNOP00000069619 |
| Ensembl nucleotide ID | ENSRNOG00000006569 |
| Gene name | Integrin beta |
| Gene symbol | Itgb8 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCGSALAFLT AALLCLHNCQ RGPALVLGAA WVFSLVLGLG QSEHNRCDSA NVVSCARCLQ 60 LGPECGWCVQ EDFVSGGSRS ERCDTVSNLI SKGCPVDSIE YLSVHVVTSS ENEINTQVTP 120 GDVSIQLHPG AEANFMLKIR PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSKKMALF 180 SHDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 240 VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300 VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 360 AIAGEIESKA ANLNNLVVEA YKKLISEVKV QLESQVHGVH FNITAICPDG ARKPGTSGCG 420 NVTSNDEVLF NVTVVMKTCD IIGGKNYAII KPIGFNETTK VHIHRSCSCQ CEDHRGLKGQ 480 CAEAAPDPKC PQCDDGKCHF DEDQFPSEAC KPQEDQPVCS GRGVCICGKC LCHKTKLGRV 540 YGQYCEKDDF SCPYLHGDVC SGHGECEGGR CQCFNGWEGD RCQCPSASAQ HCVNSKGQVC 600 SGRGTCVCGR CECTDPRSIG RLCEHCPTCH LSCSENWNCL QCLHPHNLSQ AVLDQCKASC 660 AVMEQHPVAQ TSECLSGPSY LRIFFIIFIV TFLIGLLKVL IIRQVILQWN SNKIKSSSDY 720 RVSASKKDKL ILQSVCTRAV TYRREKPEEI KMDISKLNAQ EAFRCNF 767 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB8 | 536286 | F1MVW3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 475253 | F6X717 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 102191301 | A0A452F9L9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 100053462 | F7BLS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 3696 | P26012 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 320910 | Q0VBD0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | A0A4X1TCF4 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | ITGB8 | 100009141 | P26013 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 362800 | A0A0G2JVU1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb8 | F1QN46 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005925 | focal adhesion |
| GO:0034686 | integrin alphav-beta8 complex |
| GO:1990430 | extracellular matrix protein binding |
| GO:0005178 | integrin binding |
| GO:0038023 | signaling receptor activity |
| GO:0005102 | signaling receptor binding |
| GO:0051216 | cartilage development |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0016477 | cell migration |
| GO:0001573 | ganglioside metabolic process |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0010629 | negative regulation of gene expression |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0010628 | positive regulation of gene expression |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0001570 | vasculogenesis |