| Tag | Content |
|---|---|
| Uniprot ID | P26013 |
| Entrez ID | 100009141 |
| Genbank protein ID | AAA31280.1 |
| Genbank nucleotide ID | NM_001082304.1 |
| Ensembl protein ID | ENSOCUP00000035707 |
| Ensembl nucleotide ID | ENSOCUG00000002197 |
| Gene name | Integrin beta-8 |
| Gene symbol | ITGB8 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). |
| Sequence | MCGSALGLPP AAFVRLRSCR PGPAAFLRAA WVLSLVLGLG RSENSRCASS HAVSCSECLA 60 LGPDCGWCVH EDFISGGPRS ERCDIVSNLI SKGCPVDSIE YPSVHVTIPS ENEVNTQVTP 120 GEVSIQLRPG AAANFMLKIH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF 180 SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFERA 240 VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300 VPNDGNCHLR NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 360 TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVESKVPGVY FNVTAICPDG ARKLGMEGCS 420 NVTSSDEVLF NVTVTMEKCS VTGGKNYAII KPIGFNETSK IHIHQNCGCE CEASRGGAAK 480 CAEEAPLDST CPQCQESQCH QEEAQSPSQG CKAHEDQPVC SGRGVCVCGK CLCHKMKLGK 540 VYGKYCEKDD FSCPYHHGSL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV 600 CSGRGTCVCG RCECSDPRSI GRFCEHCPTC PTACSENWNC VQCLHPHNLS QAILDQCRTS 660 CASMEQPYVE QASECFSSPS YLRIFFIIFI VTFLIGLLKI LIIRQVILQW NSSKIKSSSD 720 YRVSASKKDK LILQSVCTRA VTYRREKPEE IKLDISKLNA HETFRCNF 768 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB8 | 536286 | F1MVW3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 475253 | F6X717 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 102191301 | A0A452F9L9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 100053462 | F7BLS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 3696 | P26012 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 320910 | Q0VBD0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | A0A4X1TCF4 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | ITGB8 | 100009141 | P26013 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 362800 | A0A0G2JVU1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb8 | F1QN46 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0034686 | integrin alphav-beta8 complex |
| GO:0038023 | signaling receptor activity |
| GO:0007160 | cell-matrix adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0001570 | vasculogenesis |