| Tag | Content |
|---|---|
| Uniprot ID | A0A452F9L9 |
| Entrez ID | 102191301 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_013963182.2 |
| Ensembl protein ID | ENSCHIP00000020987 |
| Ensembl nucleotide ID | ENSCHIG00000019429 |
| Gene name | Integrin beta |
| Gene symbol | ITGB8 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MCRSALVFFT ATFVCLQKCR PGPAPFLRAA WMFSVVLGLG QSEDNRCASS NAVSCTKCLA 60 LGPDCGWCAQ EDFISGESKN ERCDTVSNLI HKGCSIDLIE YPSVRVIPSE NEINTQVTPG 120 EVLIQLHQGA EANFMLKIHP LKKYPVDLYY LVDVSASMHN NIEKLNSVGN DLSRKMAFFS 180 RDFRLGFGSY VDKTVSPYIS IHPERIHNQC SDYNLDCMPP HGYIHVLSLT ENITEFEKAV 240 HRQKISGNID TPEGGFDAML QAAVCESHIG WRKEAKRLLL VMTDQTSHLA LDSKLAGIVV 300 PNDGNCHLKN NVYVRSTSME HPSLGQLSEK LIDNNINVIF AVQGKQFHWY KDLLPLLPGT 360 IAGEIESKAA NLNNLVVEAY QKLISEVKVQ VENQVKGIYF NITAICPDGT RKPGTDGCGN 420 VTSNDEVLFN VTVTMEKCDV TGGKSYAIIK PIGFNETTKI HIHRNCSCQC DDSRGPKRKC 480 VEETFLDAKC FQCDENKCHI DEDTFSSESC KSHKDQPVCS GRGVCICGKC LCHKIKFGKV 540 YGKYCEKDDF SCPYHHGNLC AGHGECEAGR CQCFRGWEGD RCQCPSASAQ LCVSPKGQVC 600 SGRGTCVCGR CECTDPRSIG RFCEHCPTCH TGCSENWNCV QCLHPHNLSQ AILDQCKTSC 660 ALKEQHYADQ TSECFSSPSY LRIFFIIFIV TFLIGLLKVL IIRQVILQWN NNKIKSSADY 720 RVSASKKDKL ILQSVCTRAV TYRREKPEEI KMDISKLNAH ETFRSHRRRQ MC 772 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB8 | 536286 | F1MVW3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 475253 | F6X717 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 102191301 | A0A452F9L9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 100053462 | F7BLS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 3696 | P26012 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 320910 | Q0VBD0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | A0A4X1TCF4 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | ITGB8 | 100009141 | P26013 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 362800 | A0A0G2JVU1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb8 | F1QN46 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0034686 | integrin alphav-beta8 complex |
| GO:1990430 | extracellular matrix protein binding |
| GO:0038023 | signaling receptor activity |
| GO:0051216 | cartilage development |
| GO:0007160 | cell-matrix adhesion |
| GO:0001573 | ganglioside metabolic process |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0010629 | negative regulation of gene expression |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0010628 | positive regulation of gene expression |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0001570 | vasculogenesis |