Gene: ITGB8

Basic information

Tag Content
Uniprot ID F1MVW3
Entrez ID 536286
Genbank protein ID
Genbank nucleotide ID NM_001192875.1
Ensembl protein ID ENSBTAP00000004833
Ensembl nucleotide ID ENSBTAG00000003709
Gene name Integrin beta
Gene symbol ITGB8
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MCRSALVFFT ATLVCLQNCR PGPVPFLRAA WMFSVVLGLG QSEDNRCASS NAVSCTKCLA 60
LGPECGWCAQ EDFISGGSKN ERCDTVSNLI HKGCSIDLIE YPSVRVMPSE NEINTQVTPG 120
EVLIQLHQGA EANFMLKIHP LKKYPVDLYY LVDVSASMHN NIEKLNSVGN DLSRKMAFFS 180
RDFRLGFGSY VDKTVSPYIS IHPERIHNQC SDYNLDCMPP HGYIHVLSLT ENITEFEKAV 240
HRQKISGNID TPEGGFDAML QAAVCESHIG WRKEAKRLLL VMTDQTSHLA LDSKLAGIVV 300
PNDGNCHLKN NVYVRSTSME HPSLGQLSEK LIDNNINVIF AVQGKQFHWY KDLLPLLPGT 360
IAGEIESKAA NLNNLVVEAY QKLISEVKVQ VENQVKGIYF NITAICPDGT RKPGTDGCGN 420
VTSNDEVLFN VTVTMEKCDV TGGKSYAIIK PIGFNETTKI HIHRNCSCQC DDSRGPKRKC 480
VEETFLDTKC FQCDENKCHI DEDTFPSESC KSHKDQPVCS GRGVCICGKC LCHKIKFGKV 540
YGKYCEKDDF SCPYHHGNLC AGHGECEAGR CQCFRGWEGD RCQCPSASAQ LCVSPKGQVC 600
SGRGTCVCGR CECTDPRSIG RFCEHCPTCH TGCSENWNCV QCLHPHNLSQ AILDRCKTSC 660
ALKEQHYVDQ TSECLSSPSY LRIFFIIFIV TFLIGLLKVL IIRQVILQWN NNKIKSSADY 720
RVSASKKDKL ILQSVCTRAV TYRREKPEEI KMDISKLNAH ETFRCNF 767

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologITGB8536286F1MVW3Bos taurusPredictionMore>>
1:1 orthologITGB8475253F6X717Canis lupus familiarisPredictionMore>>
1:1 orthologITGB8102191301A0A452F9L9Capra hircusPredictionMore>>
1:1 orthologITGB8100053462F7BLS7Equus caballusPredictionMore>>
1:1 orthologITGB83696P26012Homo sapiensPredictionMore>>
1:1 orthologItgb8320910Q0VBD0CPOMus musculusPublicationMore>>
1:1 orthologA0A4X1TCF4Sus scrofaPredictionMore>>
1:1 orthologITGB8100009141P26013Oryctolagus cuniculusPredictionMore>>
1:1 orthologItgb8362800A0A0G2JVU1Rattus norvegicusPredictionMore>>
1:1 orthologitgb8F1QN46Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009986 cell surface
GO:0005925 focal adhesion
GO:0034686 integrin alphav-beta8 complex
GO:1990430 extracellular matrix protein binding
GO:0005178 integrin binding
GO:0038023 signaling receptor activity
GO:0051216 cartilage development
GO:0033627 cell adhesion mediated by integrin
GO:0016477 cell migration
GO:0007160 cell-matrix adhesion
GO:0001573 ganglioside metabolic process
GO:0007229 integrin-mediated signaling pathway
GO:0010629 negative regulation of gene expression
GO:0045766 positive regulation of angiogenesis
GO:0010628 positive regulation of gene expression
GO:1901388 regulation of transforming growth factor beta activation
GO:0001570 vasculogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0130 Cell adhesion
KW-1015 Disulfide bond
KW-0401 Integrin
KW-0472 Membrane
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013032 EGF-like_CS
IPR013111 EGF_extracell
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015442 Integrin_bsu-8
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS00022 EGF_1
PS00243 INTEGRIN_BETA

Pfam

Pfam ID Pfam Term
PF07974 EGF_2
PF00362 Integrin_beta
PF17205 PSI_integrin