| Tag | Content |
|---|---|
| Uniprot ID | Q0VBD0 |
| Entrez ID | 320910 |
| Genbank protein ID | AAI20692.1; AAI25344.1; |
| Genbank nucleotide ID | NM_177290.3 |
| Ensembl protein ID | ENSMUSP00000026360 |
| Ensembl nucleotide ID | ENSMUSG00000025321 |
| Gene name | Integrin beta-8 |
| Gene symbol | Itgb8 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19118215; 12050137; |
| Functional description | Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859). Required during vasculogenesis (PubMed:12050137, PubMed:16251442). |
| Sequence | MCGSALAFLT AALLSLHNCQ RGPALVLGAA WVFSLVLGLG QSEHNRCGSA NVVSCARCLQ 60 LGPECGWCVQ EDFVSGGSGS ERCDTVSSLI SKGCPVDSIE YLSVHVVTSS ENEINTQVTP 120 GEVSVQLHPG AEANFMLKVR PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSKKMALY 180 SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA 240 VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV 300 VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG 360 AIAGEIESKA ANLNNLVVEA YKKIISEVKV QLENQVHGVH FNITAICPDG ARKPGISGCG 420 NVTSNDEVLF NVTVVMKTCD IMGGKNYAII KPIGFNETTK VHIHRSCSCQ CENHRGLKGQ 480 CAEAAPDPKC PQCDDSRCHF DEDQFPSETC KPQEDQPVCS GRGVCICGKC LCHKTKLGRV 540 YGQYCEKDDF SCPYLHGDVC AGHGECEGGR CQCFSGWEGD RCQCPSASAQ HCVNSKGQVC 600 SGRGTCVCGR CECTDPRSIG RLCEHCPTCH LSCSENWNCL QCLHPHNLSQ AALDQCKSSC 660 AVMEQHRMDQ TSECLSGPSY LRIFFIIFIV TFLIGLLKVL IIRQVILQWN NNKIKSSSDY 720 RMSASKKDKL ILQSVCTRAV TYRREKPEEI KMDISKLNAQ EAFRCNF 767 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGB8 | 536286 | F1MVW3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 475253 | F6X717 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 102191301 | A0A452F9L9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 100053462 | F7BLS7 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ITGB8 | 3696 | P26012 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 320910 | Q0VBD0 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | A0A4X1TCF4 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | ITGB8 | 100009141 | P26013 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgb8 | 362800 | A0A0G2JVU1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | itgb8 | F1QN46 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005178 | integrin binding | IBA |
| GO:0038023 | signaling receptor activity | IEA |
| GO:1990430 | extracellular matrix protein binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001570 | vasculogenesis | ISS |
| GO:0001570 | vasculogenesis | ISO |
| GO:0001573 | ganglioside metabolic process | IMP |
| GO:0007160 | cell-matrix adhesion | IEA |
| GO:0007229 | integrin-mediated signaling pathway | IBA |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010629 | negative regulation of gene expression | ISO |
| GO:0016477 | cell migration | IBA |
| GO:0033627 | cell adhesion mediated by integrin | IBA |
| GO:0045766 | positive regulation of angiogenesis | ISO |
| GO:0051216 | cartilage development | ISO |
| GO:1901388 | regulation of transforming growth factor beta activation | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005925 | focal adhesion | IBA |
| GO:0009986 | cell surface | ISO |
| GO:0034686 | integrin alphav-beta8 complex | ISO |
| GO:0034686 | integrin alphav-beta8 complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-2129379 | Molecules associated with elastic fibres | IEA |
| R-MMU-216083 | Integrin cell surface interactions | IEA |