Gene: LOXL3

Basic information

Tag Content
Uniprot ID A0A2I3SAT0; A0A2J8KV41;
Entrez ID 459340
Genbank protein ID JAA10594.1; JAA12392.1; JAA26265.1; JAA35363.1; JAA10595.1; JAA35364.1;
Genbank nucleotide ID XM_001161542.5; XM_016948840.1;
Ensembl protein ID ENSPTRP00000074091
Ensembl nucleotide ID ENSPTRG00000012099
Gene name Lysyl oxidase homolog
Gene symbol LOXL3
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
Sequence
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI 60
QRAGEWGTIC DDDFTLQAAH VLCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS 120
VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR 180
PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS 240
FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGAPAVVS CVPGPLYAAS SGQKKQQQSK 300
PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAQAALSGA 360
RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS 420
GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG 480
NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE 540
TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 600
WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ 660
GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH 720
RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII 753

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologLOXL3613599E1BFC8Bos taurusPredictionMore>>
1:1 orthologLOXL3483101E2QYZ4Canis lupus familiarisPredictionMore>>
1:1 orthologLOXL3102170055A0A452FS61Capra hircusPredictionMore>>
1:1 orthologLOXL384695P58215Homo sapiensPredictionMore>>
1:1 orthologLoxl316950Q9Z175CPOE12.5, E13.5, E14.5, E15.5, E16.5Mus musculusPublicationMore>>
1:1 orthologLOXL3459340A0A2I3SAT0Pan troglodytesPredictionMore>>
1:1 orthologLOXL3F1SNV7Sus scrofaPredictionMore>>
1:1 orthologLOXL3G1U7Y3Oryctolagus cuniculusPredictionMore>>
1:1 orthologLoxl3312478D3ZP82Rattus norvegicusPredictionMore>>
1:1 orthologloxl3b336266B8A4W9Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005615 extracellular space
GO:0016020 membrane
GO:0005634 nucleus
GO:0005507 copper ion binding
GO:0001968 fibronectin binding
GO:0004720 protein-lysine 6-oxidase activity
GO:0005044 scavenger receptor activity
GO:0030199 collagen fibril organization
GO:0001837 epithelial to mesenchymal transition
GO:1905590 fibronectin fibril organization
GO:0006954 inflammatory response
GO:0030324 lung development
GO:2000329 negative regulation of T-helper 17 cell lineage commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0018057 peptidyl-lysine oxidation
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:0060021 roof of mouth development
GO:0061053 somite development
GO:0021510 spinal cord development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0186 Copper
KW-1015 Disulfide bond
KW-0886 LTQ
KW-0479 Metal-binding
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0801 TPQ

Interpro

InterPro ID InterPro Term
IPR001695 Lysyl_oxidase
IPR019828 Lysyl_oxidase_CS
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS00926 LYSYL_OXIDASE
PS00420 SRCR_1
PS50287 SRCR_2

Pfam

Pfam ID Pfam Term
PF01186 Lysyl_oxidase
PF00530 SRCR