| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3SAT0; A0A2J8KV41; |
| Entrez ID | 459340 |
| Genbank protein ID | JAA10594.1; JAA12392.1; JAA26265.1; JAA35363.1; JAA10595.1; JAA35364.1; |
| Genbank nucleotide ID | XM_001161542.5; XM_016948840.1; |
| Ensembl protein ID | ENSPTRP00000074091 |
| Ensembl nucleotide ID | ENSPTRG00000012099 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | LOXL3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI 60 QRAGEWGTIC DDDFTLQAAH VLCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS 120 VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR 180 PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS 240 FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGAPAVVS CVPGPLYAAS SGQKKQQQSK 300 PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAQAALSGA 360 RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS 420 GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG 480 NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE 540 TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 600 WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ 660 GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH 720 RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII 753 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005507 | copper ion binding |
| GO:0001968 | fibronectin binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0030199 | collagen fibril organization |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:1905590 | fibronectin fibril organization |
| GO:0006954 | inflammatory response |
| GO:0030324 | lung development |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0018057 | peptidyl-lysine oxidation |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |