| Tag | Content |
|---|---|
| Uniprot ID | F1SNV7 |
| Entrez ID | |
| Genbank protein ID | HDA59312.1; HDA38447.1; HDA87306.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000008824 |
| Ensembl nucleotide ID | ENSSSCG00000008266 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | LOXL3 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MRPVSVWQWS PQGLLLCLLC NLCLGSPSPS TAPEMRAGSQ DLRFRLAGFP RKPFEGRVEI 60 QRAGEWGTIC DDDFTLQAAH VLCRELGFTE ATGWTHSAKY GPGTGRIWLD NLNCRGTEQS 120 VTECASRGWG NSDCTHDEDA GVICKDERLP GFSDSNVIEV DHHLQVEEVR LRPAVVGRGR 180 RPLPVTEGLV EVRLPEGWSQ VCDKGWSAHN SHVVCGMLGF PSEKRVNVAF YRLLAQRQQH 240 SFGLHGVACV GTEAHLSLCS LEFYRANDTT RCPGGAPAVV SCVPSPLYAA SSGQKKQQSK 300 PQGEARVRLK GGAHPGEGRV EVLKAGTWGT VCDRKWDLQA ASVVCRELGF GSAREALTGA 360 RMGQGMGAIH LSEVRCSGQE PSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGVETKIRLS 420 GGRSRHEGRV EVQIGGPGSL RWGLICGDDW GTLEAMVVCR QLGLGYANHG LQETWYWDSG 480 NVTEVVMSGV RCTGTELSLD QCAHHGTHVA CKRTGTRFTA GVICSETASD LLLHSALVQE 540 TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 600 WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ 660 GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH 720 RIWVHNCHIG DAFSEEANRK FERYPGQTSN QII 753 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005507 | copper ion binding |
| GO:0001968 | fibronectin binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0030199 | collagen fibril organization |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:1905590 | fibronectin fibril organization |
| GO:0006954 | inflammatory response |
| GO:0030324 | lung development |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0018057 | peptidyl-lysine oxidation |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |