| Tag | Content |
|---|---|
| Uniprot ID | D3ZP82 |
| Entrez ID | 312478 |
| Genbank protein ID | EDL91104.1 |
| Genbank nucleotide ID | NM_001107866.2 |
| Ensembl protein ID | ENSRNOP00000074073 |
| Ensembl nucleotide ID | ENSRNOG00000061373 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | Loxl3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MRAVNVCYCC PWRLLLLHFL CSSSMGSPSP STDPEKKVGS QGLRFRLAGF PRKPYEGRVE 60 IQRAGEWGTI CDDDFTLQAA HVLCRELGFT EATGWTHSAK YGPGTGRIWL DNLSCKGTEG 120 SVTECASRGW GNSDCTHDED AGVICKDQRL PGFSDSNVIE VDHQLQVEEV RLRPAVEWGR 180 RPLPVTEGLV EVRLPEGWSQ VCDKGWSAHN SHVVCGMLGF PGEKRVNMAF YRMLAQKKQH 240 SFGLHSVACV GTEAHLSLCS LEFYRANDTT RCAGGSPAVV SCMLGPLYAT STGQKKQQHS 300 KPQGEASVRL KGGAHPGEGR VEVLKAGTWG TVCDRKWDLQ AASVVCRELG FGTAREALSG 360 ARMGQGMGAI HLSEVRCSGQ EPSLWKCPSK NITAEDCSHS QDAAVRCNLP YTGVETKIRL 420 SGGRSRYEGR VEVQIGVPGH LRWGLICGDD WGTLEAMVAC RQLGLGYANH GLQETWYWDS 480 GNVTEVVMSG VRCTGSELSL NQCAHHNTHV TCKRTGTRFT AGVICSETAS DLLLHSALVQ 540 ETAYIEDRPL HMLYCAAEEN CLASSARSAN WPYGHRRLLR FSSQIHNLGR ADFRPKAGRH 600 SWVWHECHGH YHSMDIFTHY DILTPNGTKV AEGHKASFCL EDTECQEDVS KRYECANFGE 660 QGITVGCWDL YRHDIDCQWI DITDVKPGNY ILQVVINPNF EVAESDFTNN AMKCNCKYDG 720 HRIWVHNCHI GDAFSEEANR RFERYPGQTS NQIV 754 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005507 | copper ion binding |
| GO:0001968 | fibronectin binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0030199 | collagen fibril organization |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:1905590 | fibronectin fibril organization |
| GO:0006954 | inflammatory response |
| GO:0030324 | lung development |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0018057 | peptidyl-lysine oxidation |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |