| Tag | Content |
|---|---|
| Uniprot ID | B8A4W9; A4QP70; A6MH33; B8A5R6; B8A5R8; E7EY82; Q5CZM0; |
| Entrez ID | 336266 |
| Genbank protein ID | ABM86970.1; AAH90801.1; AAI39678.1; |
| Genbank nucleotide ID | NM_001145684.2 |
| Ensembl protein ID | ENSDARP00000109545; ENSDARP00000103878; |
| Ensembl nucleotide ID | ENSDARG00000039563 |
| Gene name | Lysyl oxidase homolog 3B |
| Gene symbol | loxl3b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (By similarity). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (By similarity). Can mediate oxidation of lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues (By similarity). Required for maturation of neural crest derived cartilage elements (PubMed:21244857). |
| Sequence | MELHQWCRHI IVFLLNVWIP SCFAQTTPPA RSSPTPTPQT ADNPDSLKFR LSGFPRKHNE 60 GRIEVFYKGE WGTICDDDFS LANAHVLCRQ LGFVSATGWT HSAKYGKGAG KIWLDNVQCS 120 GSERSVSVCK SRGWGNSDCT HDEDAGVICK DERLPGFVDS NVIEVQVDEN RVEEVRLRPV 180 FTTATKRMPV TEGVVEVKNK DGWAQICDIG WTPKNTHVVC GMMGFPHEKK VNKNFYKLYA 240 ERQKNFFLVH SVACLGTEVH LAACPLEFNY GNATESCPGG MPAVVSCVPG PLYTQSPTMK 300 KKLKMPPTTR LKGGAKYGEG RVEVLKGSEW GTVCDDRWNL VSASVVCREM GFGSAKEALT 360 GASMGKGLGP IHMNEVQCTG NERSLWSCRY KNITAEDCKH TEDASVRCNV PYMGYEKTVR 420 ILGGRTRYEG RVEVLHREAD GTLRWGLICG EGWGTQEAMV LCRQLGLGYA NHGLQVRLSG 480 GRSPYEGRVE VRVGQRWGSV CSEGWSTKEA MVLCRQLGLG FSMHAITETW YWDSSNVTDM 540 VMSGVKCTGD EMSISQCQHH RTVNCQKAAA RFAAGVICSE TASDLVLNAP LVQQTTYIED 600 RPLHMLYCAA EEDCLSKSAA SANWPYGHRR LLRFSSQIHN IGRADFRPKA GRHSWVWHAC 660 HGHYHSMDIF THYDLMSANG TKVAEGHKAS FCLEDTDCDE GVSKRYKCAN FGEQGITVGC 720 WDLYRHDIDC QWIDITDVKP GNYILQVVIN PNYEVSESDF TNNAMKCNCK YDGHRIWVHN 780 CHIGDAFSEE AEKKFEKYPG QLNNQIS 807 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005507 | copper ion binding |
| GO:0001968 | fibronectin binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0030199 | collagen fibril organization |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:1905590 | fibronectin fibril organization |
| GO:0006954 | inflammatory response |
| GO:0030324 | lung development |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| GO:0018057 | peptidyl-lysine oxidation |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |