| Tag | Content |
|---|---|
| Uniprot ID | Q9Z175; Q91VN8; Q9JJ39; |
| Entrez ID | 16950 |
| Genbank protein ID | AAH11298.1; AAC95338.1; EDK99047.1; BAC27016.1; AAC83205.1; |
| Genbank nucleotide ID | NM_013586.4 |
| Ensembl protein ID | ENSMUSP00000000707 |
| Ensembl nucleotide ID | ENSMUSG00000000693 |
| Gene name | Lysyl oxidase homolog 3 |
| Gene symbol | Loxl3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.5, E14.5, E15.5, E16.5 |
| Data sources | Manually collected |
| Reference | 26307084 |
| Functional description | Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:26307084). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity). |
| Sequence | MRAVSVWYCC PWGLLLLHCL CSFSVGSPSP SISPEKKVGS QGLRFRLAGF PRKPYEGRVE 60 IQRAGEWGTI CDDDFTLQAA HVLCRELGFT EATGWTHSAK YGPGTGRIWL DNLSCRGTEG 120 SVTECASRGW GNSDCTHDED AGVICKDQRL PGFSDSNVIE VEHQLQVEEV RLRPAVEWGR 180 RPLPVTEGLV EVRLPEGWSQ VCDKGWSAHN SHVVCGMLGF PGEKRVNMAF YRMLAQKKQH 240 SFGLHSVACV GTEAHLSLCS LEFYRANDTT RCSGGNPAVV SCVLGPLYAT FTGQKKQQHS 300 KPQGEARVRL KGGAHQGEGR VEVLKAGTWG TVCDRKWDLQ AASVVCRELG FGTAREALSG 360 ARMGQGMGAI HLSEVRCSGQ EPSLWRCPSK NITAEDCSHS QDAGVRCNLP YTGVETKIRL 420 SGGRSRYEGR VEVQIGIPGH LRWGLICGDD WGTLEAMVAC RQLGLGYANH GLQETWYWDS 480 GNVTEVVMSG VRCTGSELSL NQCAHHSSHI TCKKTGTRFT AGVICSETAS DLLLHSALVQ 540 ETAYIEDRPL HMLYCAAEEN CLASSARSAN WPYGHRRLLR FSSQIHNLGR ADFRPKAGRH 600 SWVWHECHGH YHSMDIFTHY DILTPNGTKV AEGHKASFCL EDTECQEDVS KRYECANFGE 660 QGITVGCWDL YRHDIDCQWI DITDVKPGNY ILQVVINPNF EVAESDFTNN AMKCNCKYDG 720 HRIWVHNCHI GDAFSEEANR RFERYPGQTS NQIV 754 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001968 | fibronectin binding | IDA |
| GO:0004720 | protein-lysine 6-oxidase activity | ISO |
| GO:0004720 | protein-lysine 6-oxidase activity | IBA |
| GO:0004720 | protein-lysine 6-oxidase activity | IDA |
| GO:0005044 | scavenger receptor activity | IEA |
| GO:0005507 | copper ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001837 | epithelial to mesenchymal transition | ISS |
| GO:0001837 | epithelial to mesenchymal transition | ISO |
| GO:0006897 | endocytosis | IEA |
| GO:0006954 | inflammatory response | IBA |
| GO:0006954 | inflammatory response | IMP |
| GO:0018057 | peptidyl-lysine oxidation | ISO |
| GO:0018057 | peptidyl-lysine oxidation | IBA |
| GO:0018057 | peptidyl-lysine oxidation | IDA |
| GO:0021510 | spinal cord development | IMP |
| GO:0030199 | collagen fibril organization | IBA |
| GO:0030324 | lung development | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISS |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0060021 | roof of mouth development | IMP |
| GO:0061053 | somite development | IMP |
| GO:1905590 | fibronectin fibril organization | IMP |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment | IMP |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005615 | extracellular space | HDA |
| GO:0005615 | extracellular space | IDA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0016020 | membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1474290 | Collagen formation | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-2022090 | Assembly of collagen fibrils and other multimeric structures | IEA |
| R-MMU-2243919 | Crosslinking of collagen fibrils | IEA |