| Tag | Content |
|---|---|
| Uniprot ID | G1U7Y3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000025543 |
| Ensembl nucleotide ID | ENSOCUG00000027040 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | LOXL3 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MPLGLPGARR RHREPADASP ERAEQLRGHV TGLCGSHAPL APSLPALSLT LAPLGFDTPC 60 PPLPWSQSAD SAGRAALPSR PRPWPPAVLS ALPGPAGVRR GRGRGRTGQG RSRRPPPAAL 120 GGGAEEPGGR GSGSPVLGLL SGTRTLLEAP RAPLSQSQAF PAMRPVGVWQ WSPWGLLLCL 180 LCSSGWGSPS PSASPEKRPG SEGLRFRLAG YPRKPSEGRV EIQRAGEWGT ICDDDFTLQA 240 AHVLCRELGF TEATGWTHSA KYGPGTGRIW LDNLSCSGTE QSVTECASRG WGNSDCTHDE 300 DAGVICKDER LPGFSDSNVI EVEHQLQVEE VRLRPAVGWG RRPLPVTEGL VEVRLPDGWS 360 QVCDKGWSAH NSHVVCGMLG FPSEKRVNTA FYRLLAQRQQ HSFGLHGVAC LGTEAHLSLC 420 PLEFYRANDT ARCPGGAPAV VSCVPGPLYT ASSSQKKQQQ SKPQGEARVR LKGGAHPGEG 480 RVEVLKAGTW GTVCDRKWDL QAASVVCREL GFGSAREALS GARMGQGMGA IHLSEVRCSG 540 QEPSLWKCSH KNITAEDCSH SQDAGVRCNL PYTGVETKIR LSGGRSRHEG RVEVQTGGSG 600 PPRWGLICGD DWGTLEAMVV CRQLGLGYAN HGLQETWYWD SGNITEVVMS GVRCTGTELS 660 LDQCAHHSTH ISCKRPGTRF TAGVICSETA SDLLLHSALV QETAYIEDRP LHMLYCAAEE 720 NCLASSARSA NWPYGHRRLL RFSSQIHNLG RADFRPKAGR HSWVWHECHG HYHSMDIFTH 780 YDILTPNGTK VAEGHKASFC LEDTECQEDV SKRYECANFG EQGITVGCWD LYRHDIDCQW 840 IDITDVKPGN YILQVVINPN FEVAESDFTN NAMKCNCKYD GHRIWVHNCH IGDAFSEEAN 900 RRFERYPGQT SNQIV 915 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016020 | membrane |
| GO:0005507 | copper ion binding |
| GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
| GO:0005044 | scavenger receptor activity |