| Tag | Content |
|---|---|
| Uniprot ID | E2QYZ4 |
| Entrez ID | 483101 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_847431.4 |
| Ensembl protein ID | ENSCAFP00000012314 |
| Ensembl nucleotide ID | ENSCAFG00000008358 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | LOXL3 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MRPVSIRQWS PWGLLLCLLC SSCLGSPSPT TAPEKMAGSQ GLRFRLAGFP RKPFEGRVEI 60 QRAGEWGTIC DDDFTLQAAH VLCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS 120 VSECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EQHLQVEEVR LRPAVGRGRR 180 PLPVTEGLVE VRLPDGWSQV CDNGWSAQNS HVVCGMLGFP GEKRVNTAFY RLLAQRQQHS 240 FGLHGVACVG TEAHLSLCSL EFYRANDTTR CPGGAPAVVS CVPGPLYAVS SDQKKQQQSK 300 PQGETRVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLQA ASVVCRELGF GSAREALSGA 360 RMGQGMGAIH LSEVQCSGQE PSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGVETKIRLS 420 GGRSPHEGRV EVQIGGLGPL RWGLICGDDW GTLEAMVVCR QLGLGYANHG LQETWYWDSG 480 NTTEVVMSGV RCTGSELSLD QCAHHGTHVA CKRTGTRFTA GVICSETASD LLLHSALVQE 540 TAYIEDRPLH MLYCAAEENC LARSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 600 WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ 660 GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH 720 RIWVHNCHIG DAFSEEANRK FERYPGQTSN QII 753 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005507 | copper ion binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0030199 | collagen fibril organization |
| GO:0006954 | inflammatory response |
| GO:0018057 | peptidyl-lysine oxidation |