| Tag | Content |
|---|---|
| Uniprot ID | A0A452FS61 |
| Entrez ID | 102170055 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005686317.3 |
| Ensembl protein ID | ENSCHIP00000027058 |
| Ensembl nucleotide ID | ENSCHIG00000023130 |
| Gene name | Lysyl oxidase homolog |
| Gene symbol | LOXL3 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). |
| Sequence | MGPVSVWQWS LWGLLLCLLC SLCLGSPTPS TAPEKRAGSQ GLRFRLAGFP RKPFEGRVEI 60 QRAGEWGTIC DDDFTLQAAH VLCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTERS 120 VTECASRGWG NSDCTHDEDA GVICKDERLP GFSDSNVIEV EHHLQVEEVR LRPAVGRGRR 180 PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVICGMLGFP SEKRVNVAFY RLLAQRQQHS 240 FGLHGVACVG TEAHLSLCSL EFYRANDTAR CLGGAPAVVS CVPSPLYAAS SGQKKQQSKP 300 QGEVRVRLKG GAHPGEGRVE VLKAGTWGTV CDRKWDLQAA SVVCRELGFG SAREALSGAR 360 MGQGMGAIHL SEVRCSGQEL SLWKCPHKNI TAEDCSHSQD AGVRCNLPYT GVETKIRLSG 420 GRSRHEGRVE VQIGGPGSFR WGLICGDDWG TLEAMVACRQ LGLGYANHGL QETWYWDSGN 480 VTEVVMSGVR CTGTELSLDQ CAHHGTHVTC RRTGSRFTAG VICSETASDL LLHSALVQET 540 AYIEDRPLHM LYCAAEENCL ASSARSANWP YGHRRLLRFS SQIHNLGRAD FRPKAGRHSW 600 VWHECHGHYH SMDIFTHYDI LTPNGTKVAE GHKASFCLED TECQEDVSKR YECANFGEQG 660 ITVGCWDLYR HDIDCQWIDI TDVKPGNYIL QVVINPNFEV AESDFTNNAM KCNCKYDGHR 720 IWVHNCHIGD AFSEEANRRF ERYPGQTSNQ II 752 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LOXL3 | 613599 | E1BFC8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 483101 | E2QYZ4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 102170055 | A0A452FS61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | 84695 | P58215 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Loxl3 | 16950 | Q9Z175 | CPO | E12.5, E13.5, E14.5, E15.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | LOXL3 | 459340 | A0A2I3SAT0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LOXL3 | F1SNV7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LOXL3 | G1U7Y3 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Loxl3 | 312478 | D3ZP82 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | loxl3b | 336266 | B8A4W9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0016020 | membrane |
| GO:0005634 | nucleus |
| GO:0005507 | copper ion binding |
| GO:0001968 | fibronectin binding |
| GO:0004720 | protein-lysine 6-oxidase activity |
| GO:0005044 | scavenger receptor activity |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:1905590 | fibronectin fibril organization |
| GO:0006954 | inflammatory response |
| GO:0030324 | lung development |
| GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0018057 | peptidyl-lysine oxidation |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| GO:0060021 | roof of mouth development |
| GO:0061053 | somite development |
| GO:0021510 | spinal cord development |