Gene: CDH2

Basic information

Tag Content
Uniprot ID A0A452F6F0
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000019845
Ensembl nucleotide ID ENSCHIG00000018662
Gene name Uncharacterized protein
Gene symbol CDH2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Cadherins are calcium-dependent cell adhesion proteins.
Sequence
EGTGCHFPKD IQEAPSPDSE AFYLFIFTVK FSNCNGKRKV QYESSEPADF KVDEDGMVYA 60
VRSFPLSSEH SKFLIYAQDK ETQEKWQVAV KLSLRPALPE DSVKESREIE EIVFPRQVTK 120
HNGYLQRQKR DWVIPPINLP ENSRGPFPQE LVRIRSDRDK NLSLRYSVTG PGADQPPTGI 180
FIINPISGQL SVTKPLDREL IARFHLRAHA VDINGNQVEN PIDIVINVID MNDNRPEFLH 240
QVWNGTVPEG SKPGTYVMTV TAIDADDPNA LNGMLRYRIL SQAPSTPSPN MFTINNETGD 300
IITVAAGLDR EKVQQYTLII QATDMEGNPT YGLSNTATAV ITVTDVNDNP PEFTAMTFYG 360
EVPENRVDVI VANLTVTDKD QPHTPAWNAV YRISGGDPAG RFAIQTDPNS NDGLVTVVKP 420
IDFETNRMYV LTVAAENQVP LAKGIQHPPQ STATVSVTVI DVNENPYFAP NPKIIRQEEG 480
LHAGTMLTTF TAQDPDRYMQ QNIRYTKLSD PANWLKIDSV NGQITTIAVL DRESPNVKNN 540
IYNATFLASD NGIPPMSGTG TLQIYLLDIN DNAPQVLPQE AEICETPDPN SINITALDYD 600
IDPNAGPFAF DLPLSPVTIK RNWTITRLNG DFAQLNLKIK FLEAGIYEVP IIITDSGNPP 660
KSNISILRVK VCQCDSNGDC TDVDRIVGAG LGTGAIIAIL LCIIILLILV LMFVVWMKRR 720
DKERQAKQLL IDPEDDVRDN ILKYDEEGGG EEDQDYDLSQ LQQPDTVEPD AIKPVGIRRL 780
DERPIHAEPQ YPVRSAAPHP GDIGDFINEG LKAADNDPTA PPYDSLLVFD YEGSGSTAGS 840
LSSLNSSSSG GEQDYDYLND WGPRFKKLAD MYGGGDD 877

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDH2P19534Bos taurusPredictionMore>>
1:1 orthologCDH2480169A0A5F4CJ70Canis lupus familiarisPredictionMore>>
1:1 orthologCDH2A0A452F6F0Capra hircusPredictionMore>>
1:1 orthologCDH21000P19022Homo sapiensPublicationMore>>
1:1 orthologCdh2D3YYT0Mus musculusPredictionMore>>
1:1 orthologCDH2A0A2I3SSD4Pan troglodytesPredictionMore>>
1:1 orthologCDH2F1SAM3Sus scrofaPredictionMore>>
1:1 orthologCdh2G3V803Rattus norvegicusPredictionMore>>
1:1 orthologcdh2G1K2E7Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0005509 calcium ion binding
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0009966 regulation of signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0106 Calcium
KW-0130 Cell adhesion
KW-1003 Cell membrane
KW-0472 Membrane
KW-1185 Reference proteome
KW-0677 Repeat
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
IPR030051 CDH2

PROSITE

PROSITE ID PROSITE Term
PS00232 CADHERIN_1

Pfam

Pfam ID Pfam Term
PF00028 Cadherin
PF01049 Cadherin_C
PF08758 Cadherin_pro