| Tag | Content |
|---|---|
| Uniprot ID | G3V803 |
| Entrez ID | |
| Genbank protein ID | EDL76077.1; EDL76078.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000021170 |
| Ensembl nucleotide ID | ENSRNOG00000015602 |
| Gene name | Cadherin-2 |
| Gene symbol | Cdh2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Cadherins are calcium-dependent cell adhesion proteins. |
| Sequence | MCRIAGAPRT LLPLLAALLQ ASLEASGELA LCKTGFPEAV YSAVLPKDVH EGQPLLNVKF 60 SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLSAEQA KFLIYAQDKE TQEKWQVAVN 120 LSLEPSLTEE PMKEPHEIEE IVFPRQLAKH SGALQRQKRD WVIPPINLPE NSRGPFPQEL 180 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 300 NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAAY 420 RISGGDPTGR FAILTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480 TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP 540 ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 FAQLNLKIKF LEAGIYEVPI VITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 900 YGGGDD 906 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDH2 | P19534 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 480169 | A0A5F4CJ70 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDH2 | A0A452F6F0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 1000 | P19022 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Cdh2 | D3YYT0 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | A0A2I3SSD4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | F1SAM3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cdh2 | G3V803 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | cdh2 | G1K2E7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005912 | adherens junction |
| GO:0016324 | apical plasma membrane |
| GO:0016323 | basolateral plasma membrane |
| GO:0016342 | catenin complex |
| GO:0009986 | cell surface |
| GO:0030864 | cortical actin cytoskeleton |
| GO:0005916 | fascia adherens |
| GO:0005887 | integral component of plasma membrane |
| GO:0030027 | lamellipodium |
| GO:0044853 | plasma membrane raft |
| GO:0014069 | postsynaptic density |
| GO:0042383 | sarcolemma |
| GO:0045294 | alpha-catenin binding |
| GO:0008013 | beta-catenin binding |
| GO:0005509 | calcium ion binding |
| GO:0045295 | gamma-catenin binding |
| GO:0042802 | identical protein binding |
| GO:0019901 | protein kinase binding |
| GO:0019903 | protein phosphatase binding |
| GO:0048514 | blood vessel morphogenesis |
| GO:0048854 | brain morphogenesis |
| GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0016477 | cell migration |
| GO:0044331 | cell-cell adhesion mediated by cadherin |
| GO:0021987 | cerebral cortex development |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0048872 | homeostasis of number of cells |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0060563 | neuroepithelial cell differentiation |
| GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly |
| GO:0097150 | neuronal stem cell population maintenance |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:2000809 | positive regulation of synaptic vesicle clustering |
| GO:0072659 | protein localization to plasma membrane |
| GO:0060019 | radial glial cell differentiation |
| GO:0070445 | regulation of oligodendrocyte progenitor proliferation |
| GO:1902897 | regulation of postsynaptic density protein 95 clustering |
| GO:0051146 | striated muscle cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00232 | CADHERIN_1 |