Gene: Cdh2

Basic information

Tag Content
Uniprot ID D3YYT0
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSMUSP00000111516
Ensembl nucleotide ID ENSMUSG00000024304
Gene name Cadherin-2
Gene symbol Cdh2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Cadherins are calcium-dependent cell adhesion proteins.
Sequence
MKFSNCNRKR KVQYESSEPA DFKVDEDGTV YAVRSFPLTA EQAKFLIYAQ DKETQEKWQV 60
AVNLSREPTL TEEPMKEPHE IEEIVFPRQL AKHSGALQRQ KRDWVIPPIN LPENSRGPFP 120
QELVRIRSDR DKNLSLRYSV TGPGADQPPT GIFIINPISG QLSVTKPLDR ELIARFHLRA 180
HAVDINGNQV ENPIDIVINV IDMNDNRPEF LHQVWNGSVP EGSKPGTYVM TVTAIDADDP 240
NALNGMLRYR ILSQAPSTPS PNMFTINNET GDIITVAAGL DREKVQQYTL IIQATDMEGN 300
PTYGLSNTAT AVITVTDVND NPPEFTAMTF YGEVPENRVD VIVANLTVTD KDQPHTPAWN 360
AAYRISGGDP TGRFAILTDP NSNDGLVTVV KPIDFETNRM FVLTVAAENQ VPLAKGIQHP 420
PQSTATVSVT VIDVNENPYF APNPKIIRQE EGLHAGTMLT TLTAQDPDRY MQQNIRYTKL 480
SDPANWLKID PVNGQITTIA VLDRESPNVK NNIYNATFLA SDNGIPPMSG TGTLQIYLLD 540
INDNAPQVLP QEAETCETPE PNSINITALD YDIDPNAGPF AFDLPLSPVT IKRNWTINRL 600
NGDFAQLNLK IKFLEAGIYE VPIIITDSGN PPKSNISILR VKVCQCDSNG DCTDVDRIVG 660
AGLGTGAIIA ILLCIIILLI LVLMFVVWMK RRDKERQAKQ LLIDPEDDVR DNILKYDEEG 720
GGEEDQDYDL SQLQQPDTVE PDAIKPVGIR RLDERPIHAE PQYPVRSAAP HPGDIGDFIN 780
EGLKAADNDP TAPPYDSLLV FDYEGSGSTA GSLSSLNSSS SGGDQDYDYL NDWGPRFKKL 840
ADMYGGGDD 849

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDH2P19534Bos taurusPredictionMore>>
1:1 orthologCDH2480169A0A5F4CJ70Canis lupus familiarisPredictionMore>>
1:1 orthologCDH2A0A452F6F0Capra hircusPredictionMore>>
1:1 orthologCDH21000P19022Homo sapiensPublicationMore>>
1:1 orthologCdh2D3YYT0Mus musculusPredictionMore>>
1:1 orthologCDH2A0A2I3SSD4Pan troglodytesPredictionMore>>
1:1 orthologCDH2F1SAM3Sus scrofaPredictionMore>>
1:1 orthologCdh2G3V803Rattus norvegicusPredictionMore>>
1:1 orthologcdh2G1K2E7Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
CDH2rs539075T>GGenotyping29524576
CDH2rs539075T>GARMS-PCR; 29524576

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0106 Calcium
KW-0130 Cell adhesion
KW-1003 Cell membrane
KW-0472 Membrane
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0677 Repeat
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
IPR030051 CDH2

PROSITE

PROSITE ID PROSITE Term
PS00232 CADHERIN_1

Pfam

Pfam ID Pfam Term
PF00028 Cadherin
PF01049 Cadherin_C
PF08758 Cadherin_pro

Protein-protein interaction

Protein-miRNA interaction