| Tag | Content |
|---|---|
| Uniprot ID | F1SAM3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_013996117.1 |
| Ensembl protein ID | ENSSSCP00000004030 |
| Ensembl nucleotide ID | ENSSSCG00000003722 |
| Gene name | Cadherin 2 |
| Gene symbol | CDH2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Cadherins are calcium-dependent cell adhesion proteins. |
| Sequence | MCRILGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSQDVL EGQPLLNVKF 60 SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHS KFLIYAQDKE TQEKWQVAVK 120 LSLKPTLPED SMKESREIEE IVFPRQVTKH SGYLQRQKRD WVIPPINLPE NSRGPFPQEL 180 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300 NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAVY 420 RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480 TATVSVTVID VNENPYFAPN PKIIRQEEGL HTGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540 ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900 YGGGDD 906 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDH2 | P19534 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 480169 | A0A5F4CJ70 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDH2 | A0A452F6F0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 1000 | P19022 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Cdh2 | D3YYT0 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | A0A2I3SSD4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | F1SAM3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cdh2 | G3V803 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | cdh2 | G1K2E7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005912 | adherens junction |
| GO:0045177 | apical part of cell |
| GO:0016324 | apical plasma membrane |
| GO:0016323 | basolateral plasma membrane |
| GO:0016342 | catenin complex |
| GO:0009986 | cell surface |
| GO:0030864 | cortical actin cytoskeleton |
| GO:0005737 | cytoplasm |
| GO:0005916 | fascia adherens |
| GO:0099060 | integral component of postsynaptic specialization membrane |
| GO:0099059 | integral component of presynaptic active zone membrane |
| GO:0014704 | intercalated disc |
| GO:0030027 | lamellipodium |
| GO:0043005 | neuron projection |
| GO:0005886 | plasma membrane |
| GO:0044853 | plasma membrane raft |
| GO:0014069 | postsynaptic density |
| GO:0042383 | sarcolemma |
| GO:0045202 | synapse |
| GO:0045294 | alpha-catenin binding |
| GO:0008013 | beta-catenin binding |
| GO:0045296 | cadherin binding |
| GO:0005509 | calcium ion binding |
| GO:0008092 | cytoskeletal protein binding |
| GO:0045295 | gamma-catenin binding |
| GO:0042802 | identical protein binding |
| GO:0019901 | protein kinase binding |
| GO:0019903 | protein phosphatase binding |
| GO:0034332 | adherens junction organization |
| GO:0048514 | blood vessel morphogenesis |
| GO:0007420 | brain development |
| GO:0048854 | brain morphogenesis |
| GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0016477 | cell migration |
| GO:0000902 | cell morphogenesis |
| GO:0098609 | cell-cell adhesion |
| GO:0044331 | cell-cell adhesion mediated by cadherin |
| GO:0007043 | cell-cell junction assembly |
| GO:0021987 | cerebral cortex development |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0048872 | homeostasis of number of cells |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO:0007275 | multicellular organism development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0060563 | neuroepithelial cell differentiation |
| GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly |
| GO:0097150 | neuronal stem cell population maintenance |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:2000809 | positive regulation of synaptic vesicle clustering |
| GO:0072659 | protein localization to plasma membrane |
| GO:0060019 | radial glial cell differentiation |
| GO:0050770 | regulation of axonogenesis |
| GO:0070445 | regulation of oligodendrocyte progenitor proliferation |
| GO:1902897 | regulation of postsynaptic density protein 95 clustering |
| GO:0051966 | regulation of synaptic transmission, glutamatergic |
| GO:0051146 | striated muscle cell differentiation |
| GO:0007416 | synapse assembly |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00232 | CADHERIN_1 |