| Tag | Content |
|---|---|
| Uniprot ID | P19534; F1N0S5; |
| Entrez ID | |
| Genbank protein ID | CAA37677.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Cadherin-2 |
| Gene symbol | CDH2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Sequence | MCRIVGAPRT LLPLLAALLQ ASVDASGEIS LCKTGFPEDV YSAVLSRDVL EGQPLLNVKF 60 SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHS KFLIYAQDKE TQEKWQVAVK 120 LSLKPALPED SVKESREIEE IVFPRQVTKH NGYLQRQKRD WVIPPINLPE NSRGPFPQEL 180 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300 NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAIY 420 RISGGDPAGR FAIQTDPNSN DGLVTVVKPI DFETNRMYVL TVAAENQVPL AKGIQHPPQS 480 TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTVLTTFT AQDPDRYMQQ NIRYTKLSDP 540 ANWLKIDSVN GQITTIAVLD RESPNVKANI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 NAPQVLPQEA EICETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900 YGGGDD 906 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CDH2 | P19534 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 480169 | A0A5F4CJ70 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CDH2 | A0A452F6F0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | 1000 | P19022 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Cdh2 | D3YYT0 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | A0A2I3SSD4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CDH2 | F1SAM3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Cdh2 | G3V803 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | cdh2 | G1K2E7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005912 | adherens junction |
| GO:0045177 | apical part of cell |
| GO:0016342 | catenin complex |
| GO:0030054 | cell junction |
| GO:0009986 | cell surface |
| GO:0005737 | cytoplasm |
| GO:0005887 | integral component of plasma membrane |
| GO:0099060 | integral component of postsynaptic specialization membrane |
| GO:0099059 | integral component of presynaptic active zone membrane |
| GO:0014704 | intercalated disc |
| GO:0030027 | lamellipodium |
| GO:0043005 | neuron projection |
| GO:0005886 | plasma membrane |
| GO:0014069 | postsynaptic density |
| GO:0042383 | sarcolemma |
| GO:0045202 | synapse |
| GO:0045296 | cadherin binding |
| GO:0005509 | calcium ion binding |
| GO:0008092 | cytoskeletal protein binding |
| GO:0034332 | adherens junction organization |
| GO:0048514 | blood vessel morphogenesis |
| GO:0007420 | brain development |
| GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0000902 | cell morphogenesis |
| GO:0098609 | cell-cell adhesion |
| GO:0044331 | cell-cell adhesion mediated by cadherin |
| GO:0007043 | cell-cell junction assembly |
| GO:0010001 | glial cell differentiation |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO:0007275 | multicellular organism development |
| GO:0097150 | neuronal stem cell population maintenance |
| GO:0050770 | regulation of axonogenesis |
| GO:0009966 | regulation of signal transduction |
| GO:0051966 | regulation of synaptic transmission, glutamatergic |
| GO:0007416 | synapse assembly |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |