Gene: CCN2

Basic information

Tag Content
Uniprot ID H2QTR1; A0A2J8PT76;
Entrez ID
Genbank protein ID JAA41690.1
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000090133
Ensembl nucleotide ID ENSPTRG00000046307
Gene name Cellular communication network factor 2
Gene symbol CCN2
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTAASVGPVR VAFVLLLALC SRPAVGQNCS GPCRCSDEPA PRCPAGVSLV LDGCGCCRVC 60
AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 120
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 180
AYRLEDTFGP DPTMMRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 240
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCCN2281103O18739Bos taurusPredictionMore>>
1:1 orthologCCN2476202J9NTX8Canis lupus familiarisPredictionMore>>
1:1 orthologCCN2102191048A0A452G077Capra hircusPredictionMore>>
1:1 orthologCCN21490P29279Homo sapiensPredictionMore>>
1:1 orthologCcn214219P29268CPOMus musculusPublicationMore>>
1:1 orthologCCN2H2QTR1Pan troglodytesPredictionMore>>
1:1 orthologCCN2F1S3P6Sus scrofaPredictionMore>>
1:1 orthologCcn264032Q9R1E9Rattus norvegicusPredictionMore>>
1:1 orthologccn2a321449Q5RI33Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0031012 extracellular matrix
GO:0008201 heparin binding
GO:0005520 insulin-like growth factor binding
GO:0005178 integrin binding
GO:0008022 protein C-terminus binding
GO:0001525 angiogenesis
GO:0001502 cartilage condensation
GO:0007155 cell adhesion
GO:0030154 cell differentiation
GO:0016477 cell migration
GO:0007160 cell-matrix adhesion
GO:0035988 chondrocyte proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0030324 lung development
GO:0060548 negative regulation of cell death
GO:0010629 negative regulation of gene expression
GO:0001503 ossification
GO:0045597 positive regulation of cell differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0046330 positive regulation of JNK cascade
GO:0051496 positive regulation of stress fiber assembly
GO:0072593 reactive oxygen species metabolic process
GO:0032330 regulation of chondrocyte differentiation
GO:0007165 signal transduction
GO:0001894 tissue homeostasis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom

PROSITE

PROSITE ID PROSITE Term
PS01185 CTCK_1
PS01225 CTCK_2
PS00222 IGFBP_N_1
PS51323 IGFBP_N_2
PS50092 TSP1
PS01208 VWFC_1
PS50184 VWFC_2

Pfam

Pfam ID Pfam Term
PF00007 Cys_knot
PF00219 IGFBP
PF00090 TSP_1
PF00093 VWC