| Tag | Content |
|---|---|
| Uniprot ID | P29268; G5E830; Q922U0; |
| Entrez ID | 14219 |
| Genbank protein ID | AAA73135.1; AAA37628.1; EDL04783.1; AAA37627.1; AAH06783.1; |
| Genbank nucleotide ID | NM_010217.2 |
| Ensembl protein ID | ENSMUSP00000020171 |
| Ensembl nucleotide ID | ENSMUSG00000019997 |
| Gene name | CCN family member 2 |
| Gene symbol | Ccn2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 12736220 |
| Functional description | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). |
| Sequence | MLASVAGPIS LALVLLALCT RPAMGQDCSA QCQCAAEAAP HCPAGVSLVL DGCGCCRVCA 60 KQLGELCTER DPCDPHKGLF CDFGSPANRK IGVCTAKDGA PCVFGGSVYR SGESFQSSCK 120 YQCTCLDGAV GCVPLCSMDV RLPSPDCPFP RRVKLPGKCC EEWVCDEPKD RTAVGPALAA 180 YRLEDTFGPD PTMMRANCLV QTTEWSACSK TCGMGISTRV TNDNTFCRLE KQSRLCMVRP 240 CEADLEENIK KGKKCIRTPK IAKPVKFELS GCTSVKTYRA KFCGVCTDGR CCTPHRTTTL 300 PVEFKCPDGE IMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA 348 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CCN2 | 281103 | O18739 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 476202 | J9NTX8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 102191048 | A0A452G077 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 1490 | P29279 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ccn2 | 14219 | P29268 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CCN2 | H2QTR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CCN2 | F1S3P6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ccn2 | 64032 | Q9R1E9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ccn2a | 321449 | Q5RI33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001968 | fibronectin binding | ISO |
| GO:0005178 | integrin binding | IDA |
| GO:0005178 | integrin binding | IBA |
| GO:0005520 | insulin-like growth factor binding | IEA |
| GO:0008022 | protein C-terminus binding | ISO |
| GO:0008083 | growth factor activity | ISO |
| GO:0008201 | heparin binding | IBA |
| GO:0008201 | heparin binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001502 | cartilage condensation | IDA |
| GO:0001503 | ossification | IMP |
| GO:0001525 | angiogenesis | IDA |
| GO:0001525 | angiogenesis | IMP |
| GO:0001894 | tissue homeostasis | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0007155 | cell adhesion | IBA |
| GO:0007160 | cell-matrix adhesion | IDA |
| GO:0007165 | signal transduction | IBA |
| GO:0007229 | integrin-mediated signaling pathway | IDA |
| GO:0007568 | aging | IEA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IDA |
| GO:0009749 | response to glucose | IEA |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010629 | negative regulation of gene expression | IMP |
| GO:0010942 | positive regulation of cell death | ISO |
| GO:0016477 | cell migration | IDA |
| GO:0030154 | cell differentiation | IDA |
| GO:0030324 | lung development | IMP |
| GO:0032330 | regulation of chondrocyte differentiation | IMP |
| GO:0032355 | response to estradiol | IEA |
| GO:0032967 | positive regulation of collagen biosynthetic process | ISO |
| GO:0034059 | response to anoxia | IEA |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0035988 | chondrocyte proliferation | IMP |
| GO:0043200 | response to amino acid | IEA |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | ISO |
| GO:0043434 | response to peptide hormone | IEA |
| GO:0045597 | positive regulation of cell differentiation | ISO |
| GO:0046330 | positive regulation of JNK cascade | ISO |
| GO:0050867 | positive regulation of cell activation | ISO |
| GO:0051385 | response to mineralocorticoid | IEA |
| GO:0051496 | positive regulation of stress fiber assembly | ISO |
| GO:0060401 | cytosolic calcium ion transport | ISO |
| GO:0060452 | positive regulation of cardiac muscle contraction | ISO |
| GO:0060548 | negative regulation of cell death | ISO |
| GO:0060548 | negative regulation of cell death | IBA |
| GO:0061448 | connective tissue development | IMP |
| GO:0070278 | extracellular matrix constituent secretion | ISO |
| GO:0070318 | positive regulation of G0 to G1 transition | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070542 | response to fatty acid | IEA |
| GO:0071897 | DNA biosynthetic process | IEA |
| GO:0072593 | reactive oxygen species metabolic process | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IDA |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | HDA |
| GO:0005801 | cis-Golgi network | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005938 | cell cortex | ISO |
| GO:0031012 | extracellular matrix | IBA |
| GO:0031012 | extracellular matrix | IDA |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|