| Tag | Content |
|---|---|
| Uniprot ID | Q9R1E9; Q53YJ0; Q9WVS1; |
| Entrez ID | 64032 |
| Genbank protein ID | AAT08023.1; BAA82125.1; AAD39132.1; |
| Genbank nucleotide ID | NM_022266.2 |
| Ensembl protein ID | ENSRNOP00000020528 |
| Ensembl nucleotide ID | ENSRNOG00000015036 |
| Gene name | CCN family member 2 |
| Gene symbol | Ccn2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). |
| Sequence | MLASVAGPVS LALVLLLCTR PATGQDCSAQ CQCAAEAAPR CPAGVSLVLD GCGCCRVCAK 60 QLGELCTERD PCDPHKGLFC DFGSPANRKI GVCTAKDGAP CVFGGSVYRS GESFQSSCKY 120 QCTCLDGAVG CVPLCSMDVR LPSPDCPFPR RVKLPGKCCE EWVCDEPKDR TVVGPALAAY 180 RLEDTFGPDP TMMRANCLVQ TTEWSACSKT CGMGISTRVT NDNTFCRLEK QSRLCMVRPC 240 EADLEENIKK GKKCIRTPKI AKPVKFELSG CTSVKTYRAK FCGVCTDGRC CTPHRTTTLP 300 VEFKCPDGEI MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA 347 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CCN2 | 281103 | O18739 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 476202 | J9NTX8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 102191048 | A0A452G077 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 1490 | P29279 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ccn2 | 14219 | P29268 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CCN2 | H2QTR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CCN2 | F1S3P6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ccn2 | 64032 | Q9R1E9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ccn2a | 321449 | Q5RI33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0005801 | cis-Golgi network |
| GO:0005829 | cytosol |
| GO:0031012 | extracellular matrix |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0001968 | fibronectin binding |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0005520 | insulin-like growth factor binding |
| GO:0005178 | integrin binding |
| GO:0008022 | protein C-terminus binding |
| GO:0007568 | aging |
| GO:0001525 | angiogenesis |
| GO:0001502 | cartilage condensation |
| GO:0007155 | cell adhesion |
| GO:0030154 | cell differentiation |
| GO:0016477 | cell migration |
| GO:0007160 | cell-matrix adhesion |
| GO:0035988 | chondrocyte proliferation |
| GO:0061448 | connective tissue development |
| GO:0060401 | cytosolic calcium ion transport |
| GO:0071897 | DNA biosynthetic process |
| GO:0070278 | extracellular matrix constituent secretion |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0035556 | intracellular signal transduction |
| GO:0030324 | lung development |
| GO:0060548 | negative regulation of cell death |
| GO:0010629 | negative regulation of gene expression |
| GO:0001503 | ossification |
| GO:0060452 | positive regulation of cardiac muscle contraction |
| GO:0050867 | positive regulation of cell activation |
| GO:0010942 | positive regulation of cell death |
| GO:0045597 | positive regulation of cell differentiation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0070318 | positive regulation of G0 to G1 transition |
| GO:0010628 | positive regulation of gene expression |
| GO:0046330 | positive regulation of JNK cascade |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:0072593 | reactive oxygen species metabolic process |
| GO:0032330 | regulation of chondrocyte differentiation |
| GO:0043200 | response to amino acid |
| GO:0034059 | response to anoxia |
| GO:0032355 | response to estradiol |
| GO:0070542 | response to fatty acid |
| GO:0009749 | response to glucose |
| GO:0051385 | response to mineralocorticoid |
| GO:0014070 | response to organic cyclic compound |
| GO:0043434 | response to peptide hormone |
| GO:0007165 | signal transduction |
| GO:0001894 | tissue homeostasis |