| Tag | Content |
|---|---|
| Uniprot ID | O18739; Q2HJ71; Q9GL71; |
| Entrez ID | 281103 |
| Genbank protein ID | AAB66596.1; AAG30290.1; AAI13280.1; |
| Genbank nucleotide ID | NM_174030.2 |
| Ensembl protein ID | ENSBTAP00000008357 |
| Ensembl nucleotide ID | ENSBTAG00000006367 |
| Gene name | CCN family member 2 |
| Gene symbol | CCN2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). |
| Sequence | MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV LDGCGCCRVC 60 AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCVFGGTVY QSGESFQSSC 120 KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK EHTVVGPALA 180 AYRPEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR 240 PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300 LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CCN2 | 281103 | O18739 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 476202 | J9NTX8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 102191048 | A0A452G077 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CCN2 | 1490 | P29279 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ccn2 | 14219 | P29268 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CCN2 | H2QTR1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | CCN2 | F1S3P6 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ccn2 | 64032 | Q9R1E9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ccn2a | 321449 | Q5RI33 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0008201 | heparin binding |
| GO:0005520 | insulin-like growth factor binding |
| GO:0005178 | integrin binding |
| GO:0007155 | cell adhesion |
| GO:0071897 | DNA biosynthetic process |
| GO:0060548 | negative regulation of cell death |
| GO:0007165 | signal transduction |