Gene: ccn2a

Basic information

Tag Content
Uniprot ID Q5RI33
Entrez ID 321449
Genbank protein ID AJG06034.1; CAM46907.1; AAI15210.1;
Genbank nucleotide ID NM_001015041.2
Ensembl protein ID ENSDARP00000063027; ENSDARP00000150412;
Ensembl nucleotide ID ENSDARG00000042934; ENSDARG00000112741;
Gene name Cellular communication network factor 2a
Gene symbol ccn2a
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MFSGMTQSVI ALLFLTFLRW AVAQECSGQC HCPEVPPQCS PGVSLVLDTC GCCRVCAKQL 60
GELCTERDVC DPHKGLYCDY GSPSNRRIGV CTARDGATCV FGGMVYRSGE SFQSSCKYQC 120
TCLDGAVGCV PLCGMDIRLP SPDCPMPRRV KVPGKCCEEW VCDSPRQNTF VGSALAAYRE 180
EETYGPDPSM MRENCLVQTT EWSACSKTCG LGISTRVTND NRECRLEKQS RLCMVRPCES 240
HLEEKIRKGK KCIRTPRVSK PMKFEISGCT TTKSYRPKFC GVCTDGRCCT PHRTATLPME 300
FKCPDGQVMK KQMMFIKTCA CHYNCPGEND IFESMYYKKM VGDMA 345

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCCN2281103O18739Bos taurusPredictionMore>>
1:1 orthologCCN2476202J9NTX8Canis lupus familiarisPredictionMore>>
1:1 orthologCCN2102191048A0A452G077Capra hircusPredictionMore>>
1:1 orthologCCN21490P29279Homo sapiensPredictionMore>>
1:1 orthologCcn214219P29268CPOMus musculusPublicationMore>>
1:1 orthologCCN2H2QTR1Pan troglodytesPredictionMore>>
1:1 orthologCCN2F1S3P6Sus scrofaPredictionMore>>
1:1 orthologCcn264032Q9R1E9Rattus norvegicusPredictionMore>>
1:1 orthologccn2a321449Q5RI33Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0031012 extracellular matrix
GO:0005576 extracellular region
GO:0008201 heparin binding
GO:0005520 insulin-like growth factor binding
GO:0005178 integrin binding
GO:0007155 cell adhesion
GO:0043009 chordate embryonic development
GO:0060216 definitive hemopoiesis
GO:0007492 endoderm development
GO:0060548 negative regulation of cell death
GO:0030903 notochord development
GO:0031099 regeneration
GO:0007165 signal transduction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR043973 TSP1_CCN
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom

PROSITE

PROSITE ID PROSITE Term
PS01185 CTCK_1
PS01225 CTCK_2
PS51323 IGFBP_N_2
PS50092 TSP1
PS01208 VWFC_1
PS50184 VWFC_2

Pfam

Pfam ID Pfam Term
PF00007 Cys_knot
PF00219 IGFBP
PF19035 TSP1_CCN
PF00093 VWC