Gene Page: TOM1L1

Summary ?
GeneID10040
SymbolTOM1L1
SynonymsOK/KNS-CL.3|SRCASM
Descriptiontarget of myb1 like 1 membrane trafficking protein
ReferenceMIM:604701|HGNC:HGNC:11983|Ensembl:ENSG00000141198|HPRD:05266|Vega:OTTHUMG00000177816
Gene typeprotein-coding
Map location17q23.2
Pascal p-value0.031
eGeneCaudate basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17027208chr331219519TOM1L1100400.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DNER0.630.58
AL359079.10.630.55
EPHA80.610.45
ADAMTS150.610.54
SHC10.600.66
CDR20.590.52
EHD40.590.55
RGS190.590.41
RNF2200.590.49
PDE5A0.580.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.37-0.28
SYCP3-0.37-0.34
AL050337.1-0.34-0.26
AL138743.2-0.33-0.19
AC120053.1-0.31-0.32
FAM159B-0.31-0.40
GNG11-0.30-0.20
AC104794.1-0.30-0.17
C1orf54-0.29-0.19
AF347015.31-0.29-0.23

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC47GK001 | MSTP041coiled-coil domain containing 47Two-hybridBioGRID16169070 
COPS7AMGC110877COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)Two-hybridBioGRID16169070 
CUGBP1BRUNOL2 | CUG-BP | CUGBP | NAB50 | hNab50CUG triplet repeat, RNA binding protein 1Two-hybridBioGRID16169070 
CWF19L1FLJ10998CWF19-like 1, cell cycle control (S. pombe)Two-hybridBioGRID16169070 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESReconstituted ComplexBioGRID11711534 
GLUD2GDH2 | GLUDP1glutamate dehydrogenase 2Two-hybridBioGRID16169070 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11711534 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)Two-hybridBioGRID16169070 
NDC80HEC | HEC1 | KNTC2 | TID3 | hsNDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)Two-hybridBioGRID16169070 
NOMO1Nomo | PM5NODAL modulator 1Two-hybridBioGRID16169070 
PDPNAGGRUS | GP36 | GP40 | Gp38 | HT1A-1 | OTS8 | PA2.26 | T1A | T1A-2podoplaninTwo-hybridBioGRID16169070 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1Two-hybridBioGRID16169070 
PHYHLN1 | LNAP1 | PAHX | PHYH1 | RDphytanoyl-CoA 2-hydroxylaseTwo-hybridBioGRID16169070 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD11711534 
PWP2EHOC-17 | PWP2HPWP2 periodic tryptophan protein homolog (yeast)Two-hybridBioGRID16169070 
UBXN4FLJ23318 | KIAA0242 | KIAA2042 | UBXD2 | UBXDC1 | erasinUBX domain protein 4Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 7038All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 9459All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA FOREVER DN 3123All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN 11458All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 10866All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 14083All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 6536All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182119All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE UP 9761All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS UP 3521All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM SILENCED BY METHYLATION 5032All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271165All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 8947All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway