Gene Page: ARPC3

Summary
GeneID  10094
Symbol  ARPC3
Synonyms  ARC21|p21-Arc
Description  actin related protein 2/3 complex, subunit 3, 21kDa
See related  HGNC:706|MIM:604225|Ensembl:ENSG00000111229|HPRD:09175|
Locus tag  -
Gene type  protein-coding
Map location  12q24.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NAE10.840.85
CSTF30.810.80
PAK1IP10.810.83
CDC160.800.80
ZNF5960.800.83
GLT8D10.800.82
C17orf420.800.82
C7orf360.800.85
ZBED50.790.84
CCDC90B0.790.85
Top 10 negatively co-expressed genes
AF347015.15-0.70-0.70
AF347015.2-0.69-0.68
MT-CYB-0.69-0.68
AF347015.27-0.68-0.66
AF347015.8-0.67-0.67
AF347015.33-0.67-0.66
MT-CO2-0.67-0.64
AF347015.26-0.65-0.67
AF347015.31-0.65-0.66
TINAGL1-0.62-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005200structural constituent of cytoskeletonTAS9230079 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006928cell motionTAS9230079 
GO:0030833regulation of actin filament polymerizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005737cytoplasmIEA-
GO:0005885Arp2/3 protein complexTAS9230079 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR2ARP2ARP2 actin-related protein 2 homolog (yeast)-HPRD9000076 
ACTR3ARP3ARP3 actin-related protein 3 homolog (yeast)-HPRD9000076 
Arp2/3 complex subunits p21 and Arp3 interactBIND11741539 
Co-purificationBioGRID11741539 
ACTR3BARP11 | ARP3BETA | DKFZp686O24114ARP3 actin-related protein 3 homolog B (yeast)Affinity Capture-MSBioGRID17353931 
ARAP1CENTD2 | KIAA0782ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1Two-hybridBioGRID16169070 
ARPC1BARC41 | p40-ARC | p41-ARCactin related protein 2/3 complex, subunit 1B, 41kDa-HPRD9000076 
-HPRD9230079 |11721045 
ARPC2ARC34 | PNAS-139 | PRO2446 | p34-Arcactin related protein 2/3 complex, subunit 2, 34kDa-HPRD,BioGRID9230079 
-HPRD9000076 
ARPC4ARC20 | MGC13544 | p20-Arcactin related protein 2/3 complex, subunit 4, 20kDa-HPRD,BioGRID11162547 
-HPRD9000076 
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Two-hybridBioGRID16169070 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Two-hybridBioGRID16169070 
CTTNEMS1 | FLJ34459cortactinAffinity Capture-MSBioGRID11018051 
EFTUD2DKFZp686E24196 | FLJ44695 | KIAA0031 | Snrp116 | Snu114 | U5-116KDelongation factor Tu GTP binding domain containing 2Two-hybridBioGRID16169070 
LGALS4GAL4 | L36LBPlectin, galactoside-binding, soluble, 4Two-hybridBioGRID16169070 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1Two-hybridBioGRID16169070 
RPS4XCCG2 | DXS306 | FLJ40595 | SCAR | SCR10ribosomal protein S4, X-linkedTwo-hybridBioGRID9889097 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)Two-hybridBioGRID9889097 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
BIOCARTA_SALMONELLA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_CDC42RAC_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_UP 2612All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY 2412All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO 3824All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_UP 4020All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP 4126All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway


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