Gene Page: PRG4

Summary ?
GeneID10216
SymbolPRG4
SynonymsCACP|HAPO|JCAP|MSF|SZP
Descriptionproteoglycan 4
ReferenceMIM:604283|HGNC:HGNC:9364|Ensembl:ENSG00000116690|HPRD:05047|Vega:OTTHUMG00000035574
Gene typeprotein-coding
Map location1q25-q31
Fetal beta-0.026
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs631503chr172327801PRG4102160.08trans
rs2800921chr1209368740PRG4102160.03trans
rs7529880chr1232598502PRG4102160.03trans
rs12619086chr215180757PRG4102160.1trans
rs17535450chr239900012PRG4102160.05trans
rs17558168chr272151944PRG4102160.05trans
rs16829215chr2151871444PRG4102160.1trans
rs6726013chr2189064570PRG4102160.1trans
rs4684042chr310559201PRG4102160.19trans
rs1050604chr316357707PRG4102160trans
rs11706314chr345309716PRG4102160.19trans
rs9288980chr3112964991PRG4102160.14trans
rs3995908chr3112998529PRG4102160.14trans
rs7652801chr3113008605PRG4102160.14trans
rs6825572chr436215470PRG4102160.13trans
rs17088743chr458668728PRG4102160.1trans
rs17046025chr4166066605PRG4102160.11trans
rs1833564chr4181732225PRG4102160.05trans
rs416393chr59998327PRG4102160.14trans
rs10041298chr552214802PRG4102160.01trans
rs1462113chr5152693290PRG4102160.19trans
rs177521chr5152767641PRG4102160.04trans
rs545290chr5152858437PRG4102160.01trans
rs4236095chr647368686PRG4102160.04trans
rs9451867chr692659609PRG4102160trans
rs2301464chr6112029983PRG4102160.17trans
rs17704432chr6112048867PRG4102160.05trans
rs9374283chr6112053416PRG4102160.05trans
rs17072888chr6112099533PRG4102160.11trans
rs9321275chr6131493217PRG4102160.03trans
rs2398707chr72113428PRG4102160trans
rs3778948chr72123290PRG4102160.06trans
rs3778951chr72125319PRG4102160trans
rs17157992chr783349706PRG4102160.11trans
rs17215901chr8106549085PRG4102160.15trans
snp_a-21717080PRG4102160.1trans
rs13279114chr8106582168PRG4102160.1trans
rs16908578chr8139226337PRG4102160.01trans
rs16908622chr8139231604PRG4102162.41E-4trans
rs1999431chr9107564675PRG4102160.13trans
rs998410chr9117622673PRG4102160trans
rs7929546chr118502946PRG4102160.15trans
rs7102605chr118551676PRG4102160.15trans
rs10437594chr118629423PRG4102160.15trans
rs11042027chr118685450PRG4102160.15trans
rs638035chr1135509120PRG4102160.17trans
rs11820030chr1176133564PRG4102160.01trans
rs17134872chr1176139845PRG4102160trans
rs107512550PRG4102160.03trans
rs11236774chr1176234952PRG4102160trans
rs4759814chr12131455220PRG4102160.14trans
rs17055644chr1338020671PRG4102160.02trans
rs4349050chr1341958722PRG4102160.09trans
rs7982172chr1341969697PRG4102160.08trans
rs4942043chr1341978218PRG4102160.05trans
rs4402447chr1341984741PRG4102160.18trans
rs17057812chr1360753449PRG4102160trans
rs17251939chr1449430822PRG4102160.2trans
rs8061703chr1681000281PRG4102160.05trans
rs16941390chr1745050984PRG4102160.01trans
rs7236104chr1814032818PRG4102160.04trans
rs11873703chr1861448702PRG4102160.05trans
rs16967535chr1933373697PRG4102160.18trans
rs16967540chr1933375874PRG4102160.02trans
snp_a-17843740PRG4102160.02trans
rs6510303chr1933380831PRG4102160.02trans
rs16993349chr207266857PRG4102160.1trans
rs16993414chr207308537PRG4102160.1trans
rs6095741chr2048666589PRG4102160.01trans
rs4822938chr2228164049PRG4102160.08trans
rs6000401chr2237149335PRG4102163.829E-4trans
rs2982104chrX94740630PRG4102160.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR820.970.98
CSDE10.970.97
PHF200.960.97
EPM2AIP10.960.97
WDR480.960.97
VEZT0.960.96
EPC20.960.97
POLR3A0.960.97
ZMYM40.960.96
EXOC20.960.97
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.79-0.89
AF347015.31-0.79-0.88
FXYD1-0.79-0.89
IFI27-0.77-0.88
AF347015.33-0.77-0.85
HIGD1B-0.76-0.88
AF347015.27-0.76-0.85
MT-CYB-0.76-0.85
AF347015.8-0.76-0.87
TSC22D4-0.74-0.81

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MOROSETTI FACIOSCAPULOHUMERAL MUSCULAR DISTROPHY UP 2011All SZGR 2.0 genes in this pathway
KONG E2F1 TARGETS 106All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280183All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 9052All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191123All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228114All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170105All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 13899All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 14888All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS 3523All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275148All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway