Gene Page: PPP1R13L

Summary ?
GeneID10848
SymbolPPP1R13L
SynonymsIASPP|NKIP1|RAI|RAI4
Descriptionprotein phosphatase 1 regulatory subunit 13 like
ReferenceMIM:607463|HGNC:HGNC:18838|Ensembl:ENSG00000104881|HPRD:09195|Vega:OTTHUMG00000181784
Gene typeprotein-coding
Map location19q13.32
Pascal p-value0.297
Fetal beta-0.323
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
PPP1R13Lchr1945900128CTNM_001142502
NM_006663		.
.		silent
silent		SchizophreniaDNM:Fromer_2014
PPP1R13Lchr1945885917CTNM_001142502
NM_006663		.
.		silent
silent		SchizophreniaDNM:Gulsuner_2013

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg076376581945887042PPP1R13L1.71E-50.3270.015DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C30.810.80
C1QC0.800.82
ADORA30.800.80
TBXAS10.780.81
LAPTM50.780.80
SPI10.780.78
PTPN60.770.74
CSF3R0.770.72
APBB1IP0.770.78
ITGB20.760.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SCUBE1-0.30-0.25
DACT1-0.29-0.14
MYCN-0.29-0.15
NEUROD6-0.29-0.17
SRGAP1-0.29-0.17
TMC2-0.29-0.21
FAT4-0.29-0.15
ZNF124-0.29-0.20
AC004017.1-0.29-0.21
VASH2-0.29-0.14

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186114All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN 7752All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
NIELSEN LIPOSARCOMA DN 198All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway