Gene Page: RALBP1

Summary ?
GeneID10928
SymbolRALBP1
SynonymsRIP1|RLIP1|RLIP76
DescriptionralA binding protein 1
ReferenceMIM:605801|HGNC:HGNC:9841|Ensembl:ENSG00000017797|HPRD:09013|Vega:OTTHUMG00000131596
Gene typeprotein-coding
Map location18p11.3
Pascal p-value0.003
Sherlock p-value0.011
Fetal beta-1.178
DMG1 (# studies)
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg18989081189474805RALBP12.93E-9-0.0092.05E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACAN0.520.31
SYT170.500.43
FER1L60.480.37
PTGER30.480.40
ANKRD60.470.35
MS4A8B0.460.28
SGCZ0.460.27
GRIK10.460.41
SLIT30.450.37
CX3CL10.450.34
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SH2D2A-0.26-0.28
RPL14-0.25-0.24
RPL18-0.25-0.28
RPS19P3-0.25-0.25
RPL19P12-0.24-0.25
RPS13P2-0.24-0.24
RPS23-0.24-0.24
RPS6-0.24-0.26
RPL28-0.24-0.29
RPS16P1-0.24-0.29

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A2ADTAB | CLAPA2 | HIP9 | HYPJadaptor-related protein complex 2, alpha 2 subunitRLIP76 interacts with alpha-adaptin.BIND10910768 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitRLIP76 interacts with mu-2.BIND10910768 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseAffinity Capture-WesternBioGRID12887920 
CCNB1CCNBcyclin B1-HPRD,BioGRID12775724 
EPN1-epsin 1Affinity Capture-WesternBioGRID12775724 
GTF3AAP2 | TFIIIAgeneral transcription factor IIIAAffinity Capture-WesternBioGRID12775724 
HOOK2FLJ26218 | HK2hook homolog 2 (Drosophila)Two-hybridBioGRID16189514 
HSF1HSTF1heat shock transcription factor 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12621024 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-WesternBioGRID12621024 
NUMBS171numb homolog (Drosophila)Affinity Capture-WesternBioGRID12775724 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Rac1 interacts with RLIP76.BIND7673236 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID7673236 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)-HPRD,BioGRID7673236 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)RalA interacts with RalBP1.BIND15592429 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)RalA interacts with RLIP76.BIND7673236 
RALB-v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)-HPRD,BioGRID7673236 
RALB-v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)RalB interacts with RLIP76.BIND7673236 
REPS1RALBP1RALBP1 associated Eps domain containing 1Affinity Capture-Western
Reconstituted Complex		BioGRID9395447 
REPS2POB1RALBP1 associated Eps domain containing 2Affinity Capture-Western
Reconstituted Complex		BioGRID9422736 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding proteinReconstituted Complex
Two-hybrid		BioGRID11882656 |15451561 
TNFDIF | TNF-alpha | TNFA | TNFSF2tumor necrosis factor (TNF superfamily, member 2)Affinity Capture-WesternBioGRID12887920 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ATNFR1 interacts with RIP1.BIND15247912 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 2320All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 2920All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 3022All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 3825All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 11381All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX DN 2418All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 5135All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS 4429All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
CHENG IMPRINTED BY ESTRADIOL 11068All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
LOPEZ TRANSLATION VIA FN1 SIGNALING 3521All SZGR 2.0 genes in this pathway