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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: CDC37

Summary

GeneID

11140

Symbol

CDC37

Synonyms

P50CDC37

Description

cell division cycle 37 homolog (S. cerevisiae)

Locus tag

Gene type

protein-coding

Map location

19p13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0217

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0051082

unfolded protein binding

TAS

8666233

GO:0051879

Hsp90 protein binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000079

regulation of cyclin-dependent protein kinase activity

TAS

8666233

GO:0006605

protein targeting

TAS

8666233

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	11085988
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD,BioGRID	8666233 \|8703009
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	11864612
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	IKK-alpha interacts with Cdc37. This interaction was modeled on a demonstrated interaction between IKK-alpha from an unspecified species and human Cdc37.	BIND	11864612
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	An unspecified isoform of ERBB2 interacts with P50CDC37. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey P50CDC37.	BIND	15643424
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Co-crystal Structure in vitro	BioGRID	9685350 \|14718169
HSP90AA1			-	HPRD	9685350\|14718169
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	Co-purification Reconstituted Complex	BioGRID	11864612
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB		IKK-beta interacts with Cdc37. This interaction was modeled on a demonstrated interaction between IKK-beta from an unspecified species and human Cdc37.	BIND	11864612
IKBKE	IKK-i \| IKKE \| IKKI \| KIAA0151 \| MGC125294 \| MGC125295 \| MGC125297	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	Affinity Capture-MS	BioGRID	14743216
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD,BioGRID	11864612
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-MS	BioGRID	14743216
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	Affinity Capture-MS	BioGRID	14743216
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
NEK6	SID6-1512	NIMA (never in mitosis gene a)-related kinase 6	Affinity Capture-MS	BioGRID	17353931
SGK1	SGK	serum/glucocorticoid regulated kinase 1	Affinity Capture-MS	BioGRID	17353931
SMYD2	HSKM-B \| KMT3C \| MGC119305 \| ZMYND14	SET and MYND domain containing 2	Affinity Capture-MS	BioGRID	17353931
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	11085988
STIP1	HOP \| IEF-SSP-3521 \| P60 \| STI1 \| STI1L	stress-induced-phosphoprotein 1	-	HPRD	12437126
STK11	LKB1 \| PJS	serine/threonine kinase 11	-	HPRD,BioGRID	12489981
TBK1	FLJ11330 \| NAK \| T2K	TANK-binding kinase 1	Affinity Capture-MS	BioGRID	14743216

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_ILK_PATHWAY	45	32	All SZGR genes in this pathway
PID_LKB1_PATHWAY	47	37	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2	101	78	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR	18	13	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP	276	187	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN	234	147	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	84	54	All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS	58	45	All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN	64	41	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN	176	104	All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN	382	224	All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP	57	35	All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN	32	22	All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP	126	84	All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN	19	14	All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_UP	86	55	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP	71	49	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP	37	31	All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN	64	44	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0	107	72	All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN	141	92	All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7	98	63	All SZGR genes in this pathway
SANSOM_APC_TARGETS	212	121	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN	216	143	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_GENES	90	54	All SZGR genes in this pathway
HOLLEMAN_DAUNORUBICIN_B_ALL_UP	10	9	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-182	234	240	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-96	234	240	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.