Gene Page: CHRM5
Summary ?
| GeneID | 1133 |
| Symbol | CHRM5 |
| Synonyms | HM5 |
| Description | cholinergic receptor muscarinic 5 |
| Reference | MIM:118496|HGNC:HGNC:1954|HPRD:00331| |
| Gene type | protein-coding |
| Map location | 15q26 |
| Pascal p-value | 0.131 |
| Fetal beta | -0.261 |
| eGene | Caudate basal ganglia Cerebellum Cortex Hippocampus Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| ADT:Sun_2012 | Systematic Investigation of Antipsychotic Drugs and Their Targets | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 3 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs8038713 | chr15 | 34276988 | CHRM5 | 1133 | 4.26E-4 | cis | ||
| rs579975 | chr15 | 34349223 | CHRM5 | 1133 | 0.03 | cis | ||
| rs8038713 | chr15 | 34276988 | CHRM5 | 1133 | 0.03 | trans | ||
| rs6495421 | 15 | 34276570 | CHRM5 | ENSG00000184984.8 | 1.195E-7 | 0 | 15649 | gtex_brain_putamen_basal |
| rs6495422 | 15 | 34276599 | CHRM5 | ENSG00000184984.8 | 1.194E-7 | 0 | 15678 | gtex_brain_putamen_basal |
| rs6495423 | 15 | 34276680 | CHRM5 | ENSG00000184984.8 | 8.356E-8 | 0 | 15759 | gtex_brain_putamen_basal |
| rs6495424 | 15 | 34276738 | CHRM5 | ENSG00000184984.8 | 8.371E-8 | 0 | 15817 | gtex_brain_putamen_basal |
| rs6495425 | 15 | 34276895 | CHRM5 | ENSG00000184984.8 | 6.509E-8 | 0 | 15974 | gtex_brain_putamen_basal |
| rs6495426 | 15 | 34276899 | CHRM5 | ENSG00000184984.8 | 6.399E-8 | 0 | 15978 | gtex_brain_putamen_basal |
| rs8038713 | 15 | 34276989 | CHRM5 | ENSG00000184984.8 | 8.424E-8 | 0 | 16068 | gtex_brain_putamen_basal |
| rs1685119 | 15 | 34277053 | CHRM5 | ENSG00000184984.8 | 1.32E-7 | 0 | 16132 | gtex_brain_putamen_basal |
| rs517078 | 15 | 34277277 | CHRM5 | ENSG00000184984.8 | 1.271E-7 | 0 | 16356 | gtex_brain_putamen_basal |
| rs11856529 | 15 | 34277377 | CHRM5 | ENSG00000184984.8 | 1.036E-7 | 0 | 16456 | gtex_brain_putamen_basal |
| rs489832 | 15 | 34277907 | CHRM5 | ENSG00000184984.8 | 1.271E-7 | 0 | 16986 | gtex_brain_putamen_basal |
| rs71119909 | 15 | 34278958 | CHRM5 | ENSG00000184984.8 | 1.602E-8 | 0 | 18037 | gtex_brain_putamen_basal |
| rs569035 | 15 | 34281327 | CHRM5 | ENSG00000184984.8 | 1.27E-7 | 0 | 20406 | gtex_brain_putamen_basal |
| rs563663 | 15 | 34281884 | CHRM5 | ENSG00000184984.8 | 1.841E-7 | 0 | 20963 | gtex_brain_putamen_basal |
| rs511422 | 15 | 34282982 | CHRM5 | ENSG00000184984.8 | 1.27E-7 | 0 | 22061 | gtex_brain_putamen_basal |
| rs478125 | 15 | 34284310 | CHRM5 | ENSG00000184984.8 | 4.746E-8 | 0 | 23389 | gtex_brain_putamen_basal |
| rs12913747 | 15 | 34287060 | CHRM5 | ENSG00000184984.8 | 1.521E-8 | 0 | 26139 | gtex_brain_putamen_basal |
| rs544114 | 15 | 34288320 | CHRM5 | ENSG00000184984.8 | 1.196E-7 | 0 | 27399 | gtex_brain_putamen_basal |
| rs34773983 | 15 | 34290364 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 29443 | gtex_brain_putamen_basal |
| rs646950 | 15 | 34291660 | CHRM5 | ENSG00000184984.8 | 2.916E-7 | 0 | 30739 | gtex_brain_putamen_basal |
| rs536345 | 15 | 34291991 | CHRM5 | ENSG00000184984.8 | 5.407E-7 | 0 | 31070 | gtex_brain_putamen_basal |
| rs71462883 | 15 | 34292128 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 31207 | gtex_brain_putamen_basal |
| rs644585 | 15 | 34292224 | CHRM5 | ENSG00000184984.8 | 1.299E-7 | 0 | 31303 | gtex_brain_putamen_basal |
| rs11072868 | 15 | 34292591 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 31670 | gtex_brain_putamen_basal |
| rs632591 | 15 | 34292635 | CHRM5 | ENSG00000184984.8 | 5.324E-7 | 0 | 31714 | gtex_brain_putamen_basal |
| rs618868 | 15 | 34293378 | CHRM5 | ENSG00000184984.8 | 3.519E-7 | 0 | 32457 | gtex_brain_putamen_basal |
| rs604041 | 15 | 34294428 | CHRM5 | ENSG00000184984.8 | 5.674E-7 | 0 | 33507 | gtex_brain_putamen_basal |
| rs603152 | 15 | 34294637 | CHRM5 | ENSG00000184984.8 | 5.518E-7 | 0 | 33716 | gtex_brain_putamen_basal |
| rs602807 | 15 | 34294657 | CHRM5 | ENSG00000184984.8 | 5.518E-7 | 0 | 33736 | gtex_brain_putamen_basal |
| rs144378883 | 15 | 34294730 | CHRM5 | ENSG00000184984.8 | 5.526E-7 | 0 | 33809 | gtex_brain_putamen_basal |
| rs602302 | 15 | 34294792 | CHRM5 | ENSG00000184984.8 | 6.508E-7 | 0 | 33871 | gtex_brain_putamen_basal |
| rs4779652 | 15 | 34296119 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 35198 | gtex_brain_putamen_basal |
| rs6495442 | 15 | 34296424 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 35503 | gtex_brain_putamen_basal |
| rs6495443 | 15 | 34296512 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 35591 | gtex_brain_putamen_basal |
| rs202008786 | 15 | 34297179 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 36258 | gtex_brain_putamen_basal |
| rs66645361 | 15 | 34297180 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 36259 | gtex_brain_putamen_basal |
| rs7178075 | 15 | 34297495 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 36574 | gtex_brain_putamen_basal |
| rs7178446 | 15 | 34297721 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 36800 | gtex_brain_putamen_basal |
| rs7169003 | 15 | 34299326 | CHRM5 | ENSG00000184984.8 | 1.523E-8 | 0 | 38405 | gtex_brain_putamen_basal |
| rs635531 | 15 | 34299910 | CHRM5 | ENSG00000184984.8 | 1.327E-7 | 0 | 38989 | gtex_brain_putamen_basal |
| rs28870091 | 15 | 34300891 | CHRM5 | ENSG00000184984.8 | 1.908E-7 | 0 | 39970 | gtex_brain_putamen_basal |
| rs12594902 | 15 | 34305274 | CHRM5 | ENSG00000184984.8 | 7.082E-7 | 0 | 44353 | gtex_brain_putamen_basal |
| rs71119912 | 15 | 34305274 | CHRM5 | ENSG00000184984.8 | 1.287E-7 | 0 | 44353 | gtex_brain_putamen_basal |
| rs11635479 | 15 | 34306398 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 45477 | gtex_brain_putamen_basal |
| rs7162140 | 15 | 34310600 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 49679 | gtex_brain_putamen_basal |
| rs7173183 | 15 | 34312422 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 51501 | gtex_brain_putamen_basal |
| rs55805034 | 15 | 34313778 | CHRM5 | ENSG00000184984.8 | 1.891E-7 | 0 | 52857 | gtex_brain_putamen_basal |
| rs5016373 | 15 | 34314041 | CHRM5 | ENSG00000184984.8 | 1.587E-7 | 0 | 53120 | gtex_brain_putamen_basal |
| rs2702282 | 15 | 34316062 | CHRM5 | ENSG00000184984.8 | 1.531E-7 | 0 | 55141 | gtex_brain_putamen_basal |
| rs2702281 | 15 | 34317987 | CHRM5 | ENSG00000184984.8 | 1.531E-7 | 0 | 57066 | gtex_brain_putamen_basal |
| rs72718678 | 15 | 34321202 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60281 | gtex_brain_putamen_basal |
| rs12898898 | 15 | 34321205 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60284 | gtex_brain_putamen_basal |
| rs72718682 | 15 | 34321241 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60320 | gtex_brain_putamen_basal |
| rs67739072 | 15 | 34321318 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60397 | gtex_brain_putamen_basal |
| rs66530874 | 15 | 34321339 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60418 | gtex_brain_putamen_basal |
| rs7175823 | 15 | 34321526 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 60605 | gtex_brain_putamen_basal |
| rs12903907 | 15 | 34321981 | CHRM5 | ENSG00000184984.8 | 2.003E-8 | 0 | 61060 | gtex_brain_putamen_basal |
| rs4779656 | 15 | 34324603 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 63682 | gtex_brain_putamen_basal |
| rs2684939 | 15 | 34326138 | CHRM5 | ENSG00000184984.8 | 7.894E-7 | 0 | 65217 | gtex_brain_putamen_basal |
| rs201333500 | 15 | 34326639 | CHRM5 | ENSG00000184984.8 | 1.46E-8 | 0 | 65718 | gtex_brain_putamen_basal |
| rs2684940 | 15 | 34327208 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 66287 | gtex_brain_putamen_basal |
| rs11638109 | 15 | 34327659 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 66738 | gtex_brain_putamen_basal |
| rs2339352 | 15 | 34327821 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 66900 | gtex_brain_putamen_basal |
| rs34150464 | 15 | 34328305 | CHRM5 | ENSG00000184984.8 | 3.448E-7 | 0 | 67384 | gtex_brain_putamen_basal |
| rs147715948 | 15 | 34328546 | CHRM5 | ENSG00000184984.8 | 1.526E-8 | 0 | 67625 | gtex_brain_putamen_basal |
| rs35531038 | 15 | 34328853 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 67932 | gtex_brain_putamen_basal |
| rs72109981 | 15 | 34329049 | CHRM5 | ENSG00000184984.8 | 1.226E-7 | 0 | 68128 | gtex_brain_putamen_basal |
| rs11856633 | 15 | 34329327 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 68406 | gtex_brain_putamen_basal |
| rs4477671 | 15 | 34329673 | CHRM5 | ENSG00000184984.8 | 1.522E-8 | 0 | 68752 | gtex_brain_putamen_basal |
| rs112609265 | 15 | 34331290 | CHRM5 | ENSG00000184984.8 | 1.528E-8 | 0 | 70369 | gtex_brain_putamen_basal |
| rs398118727 | 15 | 34331580 | CHRM5 | ENSG00000184984.8 | 4.462E-8 | 0 | 70659 | gtex_brain_putamen_basal |
| rs7168640 | 15 | 34332969 | CHRM5 | ENSG00000184984.8 | 6.377E-8 | 0 | 72048 | gtex_brain_putamen_basal |
| rs34474029 | 15 | 34334604 | CHRM5 | ENSG00000184984.8 | 4.384E-8 | 0 | 73683 | gtex_brain_putamen_basal |
| rs8030094 | 15 | 34336882 | CHRM5 | ENSG00000184984.8 | 9.351E-8 | 0 | 75961 | gtex_brain_putamen_basal |
| rs4780203 | 15 | 34337671 | CHRM5 | ENSG00000184984.8 | 9.351E-8 | 0 | 76750 | gtex_brain_putamen_basal |
| rs35804445 | 15 | 34339521 | CHRM5 | ENSG00000184984.8 | 9.342E-8 | 0 | 78600 | gtex_brain_putamen_basal |
| rs111293185 | 15 | 34345999 | CHRM5 | ENSG00000184984.8 | 2.832E-7 | 0 | 85078 | gtex_brain_putamen_basal |
| rs62014671 | 15 | 34346918 | CHRM5 | ENSG00000184984.8 | 2.832E-7 | 0 | 85997 | gtex_brain_putamen_basal |
| rs71464844 | 15 | 34347123 | CHRM5 | ENSG00000184984.8 | 2.832E-7 | 0 | 86202 | gtex_brain_putamen_basal |
| rs9707955 | 15 | 34347255 | CHRM5 | ENSG00000184984.8 | 3.772E-7 | 0 | 86334 | gtex_brain_putamen_basal |
| rs8029344 | 15 | 34348972 | CHRM5 | ENSG00000184984.8 | 1.089E-6 | 0 | 88051 | gtex_brain_putamen_basal |
| rs8035849 | 15 | 34350333 | CHRM5 | ENSG00000184984.8 | 1.097E-6 | 0 | 89412 | gtex_brain_putamen_basal |
| rs8033781 | 15 | 34354739 | CHRM5 | ENSG00000184984.8 | 2.446E-7 | 0 | 93818 | gtex_brain_putamen_basal |
| rs112271785 | 15 | 34354772 | CHRM5 | ENSG00000184984.8 | 1.192E-6 | 0 | 93851 | gtex_brain_putamen_basal |
| rs541098 | 15 | 34358325 | CHRM5 | ENSG00000184984.8 | 2.467E-7 | 0 | 97404 | gtex_brain_putamen_basal |
| rs62014673 | 15 | 34364207 | CHRM5 | ENSG00000184984.8 | 2.467E-7 | 0 | 103286 | gtex_brain_putamen_basal |
| rs12917116 | 15 | 34364342 | CHRM5 | ENSG00000184984.8 | 2.467E-7 | 0 | 103421 | gtex_brain_putamen_basal |
| rs8039219 | 15 | 34365093 | CHRM5 | ENSG00000184984.8 | 2.533E-7 | 0 | 104172 | gtex_brain_putamen_basal |
| rs11634415 | 15 | 34367543 | CHRM5 | ENSG00000184984.8 | 2.467E-7 | 0 | 106622 | gtex_brain_putamen_basal |
| rs2705338 | 15 | 34370487 | CHRM5 | ENSG00000184984.8 | 2.382E-7 | 0 | 109566 | gtex_brain_putamen_basal |
| rs62014674 | 15 | 34373423 | CHRM5 | ENSG00000184984.8 | 2.836E-7 | 0 | 112502 | gtex_brain_putamen_basal |
| rs200233057 | 15 | 34374417 | CHRM5 | ENSG00000184984.8 | 2.979E-7 | 0 | 113496 | gtex_brain_putamen_basal |
| rs71119928 | 15 | 34374418 | CHRM5 | ENSG00000184984.8 | 2.967E-7 | 0 | 113497 | gtex_brain_putamen_basal |
| rs4779657 | 15 | 34381087 | CHRM5 | ENSG00000184984.8 | 2.851E-7 | 0 | 120166 | gtex_brain_putamen_basal |
| rs34448088 | 15 | 34384037 | CHRM5 | ENSG00000184984.8 | 3.512E-7 | 0 | 123116 | gtex_brain_putamen_basal |
| rs2339373 | 15 | 34389558 | CHRM5 | ENSG00000184984.8 | 9.825E-7 | 0 | 128637 | gtex_brain_putamen_basal |
| rs11634771 | 15 | 34390598 | CHRM5 | ENSG00000184984.8 | 2.861E-7 | 0 | 129677 | gtex_brain_putamen_basal |
| rs11634610 | 15 | 34390890 | CHRM5 | ENSG00000184984.8 | 2.861E-7 | 0 | 129969 | gtex_brain_putamen_basal |
| rs199539204 | 15 | 34391113 | CHRM5 | ENSG00000184984.8 | 2.861E-7 | 0 | 130192 | gtex_brain_putamen_basal |
| rs71884335 | 15 | 34391115 | CHRM5 | ENSG00000184984.8 | 2.859E-7 | 0 | 130194 | gtex_brain_putamen_basal |
| rs17817764 | 15 | 34392120 | CHRM5 | ENSG00000184984.8 | 1.615E-6 | 0 | 131199 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ADARB1 | 0.89 | 0.89 |
| MGAT3 | 0.88 | 0.94 |
| CYFIP2 | 0.88 | 0.88 |
| NISCH | 0.88 | 0.91 |
| SV2A | 0.87 | 0.89 |
| ZDHHC5 | 0.87 | 0.90 |
| AP1B1 | 0.87 | 0.89 |
| AP2A1 | 0.87 | 0.89 |
| TNFRSF21 | 0.87 | 0.88 |
| CNNM2 | 0.87 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.60 | -0.66 |
| AL139819.3 | -0.59 | -0.66 |
| AF347015.31 | -0.59 | -0.61 |
| GNG11 | -0.58 | -0.66 |
| HIGD1B | -0.58 | -0.62 |
| AP002478.3 | -0.57 | -0.64 |
| MT-CO2 | -0.57 | -0.60 |
| AF347015.2 | -0.57 | -0.54 |
| CLDN10 | -0.56 | -0.57 |
| AF347015.8 | -0.56 | -0.60 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004981 | muscarinic acetylcholine receptor activity | TAS | 3272174 | |
| GO:0004435 | phosphoinositide phospholipase C activity | TAS | 1905013 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0015872 | dopamine transport | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
| GO:0019226 | transmission of nerve impulse | IEA | neuron (GO term level: 5) | - |
| GO:0007197 | muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway | TAS | 8663391 | |
| GO:0007213 | acetylcholine receptor signaling, muscarinic pathway | TAS | 3272174 | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0008283 | cell proliferation | TAS | 8063729 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005886 | plasma membrane | TAS | 3272174 | |
| GO:0005887 | integral to plasma membrane | TAS | 3272174 | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 205 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME AMINE LIGAND BINDING RECEPTORS | 38 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 184 | 116 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |