SZGR2

Summary ?

GeneID	114793
Symbol	FMNL2
Synonyms	FHOD2
Description	formin like 2
Reference	MIM:616285\|HGNC:HGNC:18267\|Ensembl:ENSG00000157827\|HPRD:13545\|Vega:OTTHUMG00000154035
Gene type	protein-coding
Map location	2q23.3
Pascal p-value	0.002
Sherlock p-value	0.464
Fetal beta	0.259
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.02395
Expression	Meta-analysis of gene expression	P value: 1.73

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg25751974	2	153474786	FMNL2	2.512E-4	-0.551	0.037	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs6448932	chr4	12595798	FMNL2	114793	0.12	trans
rs6480996	chr10	54896815	FMNL2	114793	0.18	trans
rs7907658	chr10	92792387	FMNL2	114793	0.13	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	IEA		-
GO:0003700	transcription factor activity	IEA		-
GO:0017048	Rho GTPase binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0016043	cellular component organization	IEA		-
GO:0030036	actin cytoskeleton organization	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS DN	124	79	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP	178	108	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
IKEDA MIR133 TARGETS UP	43	27	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN	148	88	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1	467	251	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP	289	184	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	788	794	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	788	794	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-137	1830	1836	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-137	1830	1836	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-3p	1913	1919	m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-181	1451	1457	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-203.1	1530	1537	1A,m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-219	883	889	m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	1260	1266	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1260	1266	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-34/449	1568	1574	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-381	1215	1221	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	1302	1308	m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-493-5p	1320	1326	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	274	280	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-543	1452	1459	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FMNL2