Gene Page: IKBIP

Summary ?
GeneID121457
SymbolIKBIP
SynonymsIKIP
DescriptionIKBKB interacting protein
ReferenceMIM:609861|HGNC:HGNC:26430|Ensembl:ENSG00000166130|HPRD:08092|Vega:OTTHUMG00000170213
Gene typeprotein-coding
Map location12q23.1
Pascal p-value0.733
Fetal beta1.162
eGeneCortex
Hippocampus
Putamen basal ganglia
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
IKBIPchr1299008054CTNM_201612
NM_201613		p.121R>H
.		missense
3-UTR		SchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg184661081299038412APAF1;IKBIP1.595E-4-0.2270.032DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs45643861299023846IKBIPENSG00000166130.101.945E-60.0315045gtex_brain_putamen_basal
rs677214031299027273IKBIPENSG00000166130.101.422E-60.0311618gtex_brain_putamen_basal
rs123710971299029299IKBIPENSG00000166130.101.945E-60.039592gtex_brain_putamen_basal
rs2010560031299030691IKBIPENSG00000166130.103.271E-60.038200gtex_brain_putamen_basal
rs32174651299038708IKBIPENSG00000166130.101.805E-60.03183gtex_brain_putamen_basal
rs22783611299043207IKBIPENSG00000166130.101.82E-60.03-4316gtex_brain_putamen_basal
rs341443251299044920IKBIPENSG00000166130.101.823E-60.03-6029gtex_brain_putamen_basal
rs111095641299059900IKBIPENSG00000166130.101.828E-60.03-21009gtex_brain_putamen_basal
rs353656491299060627IKBIPENSG00000166130.101.828E-60.03-21736gtex_brain_putamen_basal
rs111095651299060813IKBIPENSG00000166130.101.828E-60.03-21922gtex_brain_putamen_basal
rs72985611299070843IKBIPENSG00000166130.102.505E-60.03-31952gtex_brain_putamen_basal
rs38159971299071023IKBIPENSG00000166130.101.828E-60.03-32132gtex_brain_putamen_basal
rs73038741299072233IKBIPENSG00000166130.102.58E-60.03-33342gtex_brain_putamen_basal
rs22887251299085026IKBIPENSG00000166130.103.004E-60.03-46135gtex_brain_putamen_basal
rs22887241299085027IKBIPENSG00000166130.103.004E-60.03-46136gtex_brain_putamen_basal
rs65388791299088094IKBIPENSG00000166130.102.507E-60.03-49203gtex_brain_putamen_basal
rs123706181299088223IKBIPENSG00000166130.101.828E-60.03-49332gtex_brain_putamen_basal
rs22887191299097911IKBIPENSG00000166130.102.275E-60.03-59020gtex_brain_putamen_basal
rs73155471299101441IKBIPENSG00000166130.102.741E-60.03-62550gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 8557All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11 6345All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway