Gene Page: TC2N

Summary ?
GeneID123036
SymbolTC2N
SynonymsC14orf47|C2CD1|MTAC2D1|Tac2-N
Descriptiontandem C2 domains, nuclear
ReferenceHGNC:HGNC:19859|Ensembl:ENSG00000165929|HPRD:11375|Vega:OTTHUMG00000171121
Gene typeprotein-coding
Map location14q32.12
Pascal p-value0.333
eGeneAnterior cingulate cortex BA24
Cortex
Frontal Cortex BA9
Hypothalamus
Nucleus accumbens basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs570355931492268096TC2NENSG00000165929.83.15739E-60.0465784gtex_brain_ba24
rs104986311492268531TC2NENSG00000165929.83.15739E-60.0465349gtex_brain_ba24
rs125896361492287743TC2NENSG00000165929.83.15009E-60.0446137gtex_brain_ba24
rs619900921492289301TC2NENSG00000165929.81.48881E-60.0444579gtex_brain_ba24
rs104986321492290744TC2NENSG00000165929.83.14231E-60.0443136gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf1020.910.92
KIAA02320.900.91
TRIP120.890.90
GAPVD10.890.90
DNAJC130.890.90
XPO40.890.90
UBR20.890.90
PIKFYVE0.890.89
MYO9A0.890.91
ERCC60.880.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.70-0.71
AF347015.21-0.70-0.73
AF347015.31-0.68-0.71
HIGD1B-0.68-0.72
MT-CO2-0.67-0.70
IFI27-0.66-0.69
ENHO-0.66-0.73
AF347015.8-0.65-0.68
TLCD1-0.64-0.67
AC021016.1-0.64-0.64

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 12145All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230115All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 12684All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP 9871All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212121All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway