Gene Page: CCR6

Summary
GeneID  1235
Symbol  CCR6
Synonyms  BN-1|CD196|CKR-L3|CKR6|CKRL3|CMKBR6|DCR2|DRY-6|GPR-CY4|GPR29|GPRCY4|STRL22
Description  chemokine (C-C motif) receptor 6
See related  HGNC:1607|MIM:601835|Ensembl:ENSG00000112486|HPRD:03498|
Locus tag  -
Gene type  protein-coding
Map location  6q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
STARD90.540.54
RAD520.510.53
PABPC1L0.510.45
PAN20.510.54
CEP1520.500.50
RTTN0.500.48
GUSB0.500.50
FANCA0.500.46
FSCN30.500.40
MYO9B0.500.53
Top 10 negatively co-expressed genes
AF347015.31-0.32-0.36
IL32-0.31-0.41
MYL3-0.31-0.36
IFI27-0.30-0.34
MT-CO2-0.30-0.33
GNG11-0.29-0.34
CXCL14-0.29-0.35
RERGL-0.29-0.41
HIGD1B-0.29-0.34
AF347015.21-0.28-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9186513 
GO:0005515protein bindingIEA-
GO:0004945angiotensin type II receptor activityIEA-
GO:0016493C-C chemokine receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007204elevation of cytosolic calcium ion concentrationTAS9223454 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0006968cellular defense responseTAS10521347 
GO:0007165signal transductionTAS9186513 
GO:0006959humoral immune responseTAS11001880 
GO:0006935chemotaxisTAS11001880 
GO:0006928cell motionTAS9186513 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS9186513 
GO:0005887integral to plasma membraneTAS9186513 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCL20CKb4 | LARC | MIP-3a | MIP3A | SCYA20 | ST38chemokine (C-C motif) ligand 20-HPRD,BioGRID9169459 |9223454 
|9294137 
DEFB103ADEFB103 | DEFB3 | HBD-3 | HBD3 | HBP-3 | HBP3defensin, beta 103A-HPRD11714836 
DEFB4DEFB-2 | DEFB102 | DEFB2 | HBD-2 | SAP1defensin, beta 4-HPRD11714836 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
REACTOME_DEFENSINS 5112All SZGR genes in this pathway
REACTOME_BETA_DEFENSINS 4210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES 5727All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
FUNG_IL2_SIGNALING_2 128All SZGR genes in this pathway
FUNG_IL2_TARGETS_WITH_STAT5_BINDING_SITES_T1 97All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_DN 3822All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
XU_CREBBP_TARGETS_DN 4431All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_DN 5535All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway


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