Gene Page: CTBP1

Summary ?
GeneID1487
SymbolCTBP1
SynonymsBARS
DescriptionC-terminal binding protein 1
ReferenceMIM:602618|HGNC:HGNC:2494|Ensembl:ENSG00000159692|HPRD:04015|Vega:OTTHUMG00000089259
Gene typeprotein-coding
Map location4p16
Pascal p-value0.026
Fetal beta-0.458
DMG2 (# studies)
eGeneMyers' cis & trans
Meta
SupportPROTEIN CLUSTERING
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0194279041211419CTBP11.473E-40.5810.031DMG:Wockner_2014
cg1321691041242411CTBP11.03E-8-0.024.45E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17799628chr9106442995CTBP114870.2trans
rs6128541chr2057917688CTBP114870.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTL6BACTL6 | BAF53Bactin-like 6B-HPRD,BioGRID12565893 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliCtBP interacts with APC.BIND15525529 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10196224 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID9858600 |11583618 
|12679040 |12829790 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)Pc2 interacts with CtBP1.BIND15592428 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCTBP1 interacts with CREBBP (CBP)BIND15834423 
CTBP1BARS | MGC104684C-terminal binding protein 1CTBP1 forms a homodimerBIND15834423 
CTBP2-C-terminal binding protein 2-HPRD,BioGRID9858600 
ELAC2ELC2 | FLJ10530 | FLJ36693 | FLJ42848 | HPC2elaC homolog 2 (E. coli)-HPRD9858600 
ELK3ERP | NET | SAP2ELK3, ETS-domain protein (SRF accessory protein 2)-HPRD10369679 
EP300KAT3B | p300E1A binding protein p300CTBP1 interacts with EP300 (p300)BIND15834423 
EVI1AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3ecotropic viral integration site 1-HPRD,BioGRID11313276 
FOXP112CC4 | FLJ23741 | HSPC215 | MGC12942 | MGC88572 | MGC99551 | QRF1 | hFKH1Bforkhead box P1-HPRD,BioGRID14701752 
FOXP2CAGH44 | DKFZp686H1726 | SPCH1 | TNRC10forkhead box P2Affinity Capture-Western
Two-hybrid		BioGRID14701752 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID11959865 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID9650586 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID10766745 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Reconstituted ComplexBioGRID11022042 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Reconstituted ComplexBioGRID11022042 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5Reconstituted ComplexBioGRID11022042 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID11022042 
HIC1ZBTB29 | hic-1hypermethylated in cancer 1-HPRD12052894 
HTTHD | IT15huntingtinHuntingtin interacts with CTBP.BIND11739372 
HTTHD | IT15huntingtin-HPRD,BioGRID11739372 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)-HPRD,BioGRID10766745 
IKZF4EOS | KIAA1782 | ZNFN1A4IKAROS family zinc finger 4 (Eos)-HPRD,BioGRID12444977 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BCTBP1 interacts with PCAFBIND15834423 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BBiochemical ActivityBioGRID9824164 
KLF12AP-2rep | AP2REP | HSPC122Kruppel-like factor 12-HPRD11373277 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Affinity Capture-Western
Far Western		BioGRID12867035 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID12829790 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1Reconstituted ComplexBioGRID15060175 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1-HPRD11509661 
PNNDRS | SDK3 | memA | pininpinin, desmosome associated protein-HPRD,BioGRID15542832 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD11583618 
RBBP8CTIP | RIMretinoblastoma binding protein 8-HPRD9535825 |11313276 
RBBP8CTIP | RIMretinoblastoma binding protein 8Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID9535825 |10196224 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)in vivoBioGRID10766745 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1Affinity Capture-WesternBioGRID12714599 
SMAD6HsT17432 | MADH6 | MADH7SMAD family member 6Affinity Capture-WesternBioGRID14645520 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinReconstituted ComplexBioGRID11959865 
TCF7L2TCF-4 | TCF4transcription factor 7-like 2 (T-cell specific, HMG-box)CtBP does not interacts with TCF-4 in mammalian cells.BIND15525529 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1-HPRD,BioGRID10995736 
ZEB1AREB6 | BZP | DELTA-EF1 | MGC133261 | NIL-2-A | NIL-2A | NIL2A | TCF8 | ZEB | ZFHEP | ZFHX1Azinc finger E-box binding homeobox 1Affinity Capture-WesternBioGRID10359772 
ZFPM2DIH3 | FOG2 | MGC129663 | MGC129664 | ZNF89B | hFOG-2zinc finger protein, multitype 2-HPRD,BioGRID10438528 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 7359All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 2624All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 4639All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN 1914All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 7657All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203135All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 10265All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway