Gene Page: CTNND1

Summary ?
GeneID1500
SymbolCTNND1
SynonymsCAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)
Descriptioncatenin delta 1
ReferenceMIM:601045|HGNC:HGNC:2515|Ensembl:ENSG00000198561|HPRD:03026|Vega:OTTHUMG00000167272
Gene typeprotein-coding
Map location11q11
Pascal p-value2.403E-6
Sherlock p-value0.26
SupportINTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.5323 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0016055Wnt receptor signaling pathwayIEA-
GO:0016337cell-cell adhesionNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005634nucleusNAS-
GO:0005737cytoplasmNAS-
GO:0030027lamellipodiumIEA-
GO:0005886plasma membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1Affinity Capture-WesternBioGRID12835311 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)CDH1(Ecad) interacts with P120ctn 3AC. This interaction was modelled on a demonstrated interaction between mouse CDH1(Ecad) and human P120ctn 3AC.BIND12707304 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD7651399 |10409703|10225956 
|10931041 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7542250 |7651399 
|7876318 |9535896 
|10409703 |12427869 
|12640114 |12707304 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-MS
Affinity Capture-Western		BioGRID12604612 |14625392 
CDH24CDH11L | FLJ25193 | MGC131880cadherin-like 24-HPRD12734196 
CDH3CDHP | HJMD | PCADcadherin 3, type 1, P-cadherin (placental)-HPRD,BioGRID8660921 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID11855855 
COL17A1BA16H23.2 | BP180 | BPAG2 | FLJ60881 | KIAA0204 | LAD-1collagen, type XVII, alpha 1-HPRD,BioGRID10321838 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDaAffinity Capture-WesternBioGRID7651399 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID9535896 |11712088 
CTTNEMS1 | FLJ34459cortactin-HPRD,BioGRID12835311 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Reconstituted ComplexBioGRID9535896 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID11821434 
FERTYK3fer (fps/fes related) tyrosine kinase-HPRD12640114 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESAffinity Capture-Western
Biochemical Activity		BioGRID12640114 |12835311 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD12151522 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinaseBiochemical ActivityBioGRID12835311 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD,BioGRID11181067 
NPHS1CNF | NPHNnephrosis 1, congenital, Finnish type (nephrin)Affinity Capture-Western
Reconstituted Complex		BioGRID15331416 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10208590 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID10835420 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD,BioGRID12370829 
PTPRMMGC166994 | PTPRL1 | R-PTP-MU | RPTPM | RPTPU | hR-PTPuprotein tyrosine phosphatase, receptor type, M-HPRD,BioGRID10753936 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID12640114 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1Affinity Capture-WesternBioGRID12640114 
ZBTB33ZNF-kaiso | ZNF348zinc finger and BTB domain containing 33-HPRD,BioGRID10207085 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 4934All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 3933All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY 2119All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY 4234All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 3332All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 5537All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS 2720All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 5631All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 7843All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB DN 2116All SZGR 2.0 genes in this pathway
IVANOV MUTATED IN COLON CANCER 139All SZGR 2.0 genes in this pathway
TONG INTERACT WITH PTTG1 5732All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 6647All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 14083All SZGR 2.0 genes in this pathway
WANG IMMORTALIZED BY HOXA9 AND MEIS1 UP 3124All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 6733All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 8349All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 9259All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY 4NQO IN WS 4026All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN OLD 3119All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 3322All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE DN 2112All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION D 6844All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 13899All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 8766All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216124All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 3727All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239156All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway