SZGR2

Summary ?

GeneID	1639
Symbol	DCTN1
Synonyms	DAP-150\|DP-150\|P135
Description	dynactin subunit 1
Reference	MIM:601143\|HGNC:HGNC:2711\|Ensembl:ENSG00000204843\|HPRD:07206\|Vega:OTTHUMG00000129963
Gene type	protein-coding
Map location	2p13
Pascal p-value	0.543
Sherlock p-value	0.31
Fetal beta	-1.376
eGene	Myers' cis & trans
Support	INTRACELLULAR TRAFFICKING G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.3203

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs7598660	chr2	73740424	DCTN1	1639	0.13	cis
rs11688718	chr2	73760938	DCTN1	1639	0.17	cis
rs4852939	chr2	73856768	DCTN1	1639	0.08	cis
rs4852316	chr2	73919657	DCTN1	1639	0.05	cis
rs17350056	chr2	73922876	DCTN1	1639	0.15	cis
rs12052539	chr2	73937152	DCTN1	1639	0.11	cis
rs17350188	chr2	73964841	DCTN1	1639	0.09	cis
rs12624267	chr2	73986930	DCTN1	1639	0.01	cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003774	motor activity	IEA		-
GO:0005515	protein binding	IPI		9722614 \|15107855
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	NAS	neurite (GO term level: 5)	17360970
GO:0007067	mitosis	NAS		1828535
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000922	spindle pole	IDA		14718566
GO:0005856	cytoskeleton	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005737	cytoplasm	TAS		1828535
GO:0030286	dynein complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTR1A	ARP1 \| CTRN1 \| FLJ52695 \| FLJ52800 \| FLJ55002	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	-	HPRD	7878030
AKTIP	FT1 \| FTS	AKT interacting protein	Affinity Capture-MS	BioGRID	17353931
APEX1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	-	HPRD	9361024
BBS4	-	Bardet-Biedl syndrome 4	Affinity Capture-Western Two-hybrid	BioGRID	15107855
BICD2	KIAA0699 \| bA526D8.1	bicaudal D homolog 2 (Drosophila)	-	HPRD	11483508 \|12447383
BZW1	BZAP45 \| KIAA0005 \| Nbla10236	basic leucine zipper and W2 domains 1	Affinity Capture-MS	BioGRID	17353931
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	-	HPRD	11425872
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	11425872
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	-	HPRD	11425872
CLIP1	CLIP \| CLIP-170 \| CLIP170 \| CYLN1 \| MGC131604 \| RSN	CAP-GLY domain containing linker protein 1	-	HPRD	12789661
DCTN2	DCTN50 \| DYNAMITIN \| RBP50	dynactin 2 (p50)	p50dynamitin (DCTN2) interacts with an unspecified isoform of p150glued (DCTN1).	BIND	15580264
DST	BP240 \| BPA \| BPAG1 \| CATX-15 \| D6S1101 \| DKFZp564B2416 \| DMH \| DT \| FLJ46791 \| KIAA0465 \| KIAA1470 \| MACF2	dystonin	-	HPRD,BioGRID	14581450
DYNC1H1	DHC1 \| DHC1a \| DKFZp686P2245 \| DNCH1 \| DNCL \| DNECL \| DYHC \| Dnchc1 \| HL-3 \| KIAA0325 \| p22	dynein, cytoplasmic 1, heavy chain 1	Affinity Capture-Western	BioGRID	14600259
DYNC1I2	DNCI2 \| FLJ21089 \| FLJ90842 \| IC2 \| MGC104199 \| MGC111094 \| MGC9324	dynein, cytoplasmic 1, intermediate chain 2	-	HPRD	8522607
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	Affinity Capture-Western	BioGRID	10189366
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	8955163
GSTK1	GST13	glutathione S-transferase kappa 1	Affinity Capture-MS	BioGRID	17353931
HAP1	HAP2 \| HIP5 \| HLP \| hHLP1	huntingtin-associated protein 1	-	HPRD,BioGRID	9361024 \|9454836
HTT	HD \| IT15	huntingtin	-	HPRD	9454836
KIF11	EG5 \| HKSP \| KNSL1 \| TRIP5	kinesin family member 11	-	HPRD,BioGRID	9235942
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	-	HPRD	15375157
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	-	HPRD	15375157
MAPRE1	EB1 \| MGC117374 \| MGC129946	microtubule-associated protein, RP/EB family, member 1	-	HPRD	12388762
PAFAH1B1	LIS1 \| LIS2 \| MDCR \| MDS \| PAFAH	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa	-	HPRD,BioGRID	11889140\|14584027
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	Affinity Capture-Western	BioGRID	12852857
RAB6A	RAB6 \| RAB6A' \| RAB6B	RAB6A, member RAS oncogene family	Reconstituted Complex Two-hybrid	BioGRID	12401177
RFXANK	ANKRA1 \| BLS \| F14150_1 \| MGC138628 \| RFX-B	regulatory factor X-associated ankyrin-containing protein	Affinity Capture-MS	BioGRID	17353931
SAR1A	SAR1 \| SARA1 \| Sara \| masra2	SAR1 homolog A (S. cerevisiae)	Sar1p (SARA1) interacts with an unspecified isoform of p150glued (DCTN1). This interaction is probably indirect and bridged by Sec23p-Sec24p.	BIND	15580264
SEC23A	CLSD \| MGC26267	Sec23 homolog A (S. cerevisiae)	Sec23A interacts with p150glued (DCTN1).	BIND	15580264
SEC24D	FLJ43974 \| KIAA0755	SEC24 family, member D (S. cerevisiae)	Sec24D interacts with p150glued (DCTN1).	BIND	15580264
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	Affinity Capture-Western	BioGRID	8991093
SPTBN2	GTRAP41 \| SCA5	spectrin, beta, non-erythrocytic 2	-	HPRD,BioGRID	11461920
TP53BP1	53BP1 \| FLJ41424 \| MGC138366 \| p202	tumor protein p53 binding protein 1	Affinity Capture-Western	BioGRID	15611139
VIM	FLJ36605	vimentin	-	HPRD,BioGRID	14600259

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG VASOPRESSIN REGULATED WATER REABSORPTION	44	30	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION	91	61	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	59	38	All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	46	34	All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE	80	51	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP	57	35	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA UP	22	12	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING	75	44	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN	54	43	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP	69	46	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
MIZUSHIMA AUTOPHAGOSOME FORMATION	19	15	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	240	246	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	240	246	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DCTN1