Gene Page: DLX5

Summary
GeneID  1749
Symbol  DLX5
Synonyms  -
Description  distal-less homeobox 5
See related  HGNC:2918|MIM:600028|Ensembl:ENSG00000105880|HPRD:02492|
Locus tag  -
Gene type  protein-coding
Map location  7q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIEAneuron, axon, neurite (GO term level: 12)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)7907794 
GO:0001501skeletal system developmentTAS7907794 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0042472inner ear morphogenesisIEA-
GO:0030326embryonic limb morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLX2TES-1 | TES1distal-less homeobox 2Reconstituted ComplexBioGRID9111364 
DLX5-distal-less homeobox 5Reconstituted ComplexBioGRID9111364 
HOXC8HOX3 | HOX3Ahomeobox C8Reconstituted ComplexBioGRID9111364 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1in vivo
Two-hybrid		BioGRID11084035 
MSX1HOX7 | HYD1msh homeobox 1Reconstituted ComplexBioGRID9111364 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD,BioGRID9111364 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD10451362 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
MAYBURD_RESPONSE_TO_L663536_DN 5632All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_UP 6841All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_7Q21_Q22_AMPLICON 7633All SZGR genes in this pathway
NADLER_HYPERGLYCEMIA_AT_OBESITY 5835All SZGR genes in this pathway
NIELSEN_GIST_VS_SYNOVIAL_SARCOMA_UP 1912All SZGR genes in this pathway
SU_PLACENTA 3018All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_UP 3920All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506211217m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-203.11451511Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-376222228m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-496131137m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-5432552611Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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