Gene Page: S1PR1

Summary
GeneID  1901
Symbol  S1PR1
Synonyms  CHEDG1|D1S3362|ECGF1|EDG-1|EDG1|FLJ58121|S1P1
Description  sphingosine-1-phosphate receptor 1
See related  HGNC:3165|MIM:601974|Ensembl:ENSG00000170989|HPRD:03578|
Locus tag  -
Gene type  protein-coding
Map location  1p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.738 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1709 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001619lysosphingolipid and lysophosphatidic acid receptor activityIEA-
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001525angiogenesisIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayTAS8626678 
GO:0007193G-protein signaling, adenylate cyclase inhibiting pathwayIEA-
GO:0007165signal transductionIEA-
GO:0008284positive regulation of cell proliferationIEA-
GO:0030155regulation of cell adhesionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS8626678 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID10921915 
GNAI1Giguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1-HPRD,BioGRID8626678 
GNAI387U6 | FLJ26559guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3-HPRD,BioGRID8626678 
HTR1A5-HT1A | 5HT1a | ADRB2RL1 | ADRBRL15-hydroxytryptamine (serotonin) receptor 1A-HPRD,BioGRID11854302 
5-HT1A interacts with EDG1. This interaction was modeled on a demonstrated interaction between 5-HT1A and EDG1 from an unspecified species.BIND11854302 
HTR1D5-HT1D | HT1DA | HTR1DA | HTRL | RDC45-hydroxytryptamine (serotonin) receptor 1D5-HT1D interacts with EDG1. This interaction was modeled on a demonstrated interaction between 5-HT1D and EDG1 from an unspecified species.BIND11854302 
-HPRD,BioGRID11854302 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptide-HPRD,BioGRID12480944 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_DN 2415All SZGR genes in this pathway
RADMACHER_AML_PROGNOSIS 7852All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
LEIN_ASTROCYTE_MARKERS 4235All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_DN 3323All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/301259265m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/1522602671A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-15511271133m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d922928m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181101910261A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-19258264m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-242642711A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/36712561262m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-320134113471Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3302502561Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-377952958m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-455133513411Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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