Gene Page: EFNB3

Summary
GeneID  1949
Symbol  EFNB3
Synonyms  EFL6|EPLG8|LERK8
Description  ephrin-B3
See related  HGNC:3228|MIM:602297|Ensembl:ENSG00000108947|HPRD:03804|
Locus tag  -
Gene type  protein-coding
Map location  17p13.1-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AK30.730.67
ACBD50.720.68
ERLIN20.720.74
KDSR0.710.68
PIK3C2A0.690.70
ARHGAP50.690.70
GALC0.690.69
ITGAV0.690.70
RNF1410.680.66
MCCC20.680.66
Top 10 negatively co-expressed genes
IL32-0.51-0.46
AF347015.21-0.44-0.30
CLEC3B-0.44-0.42
FAM159B-0.41-0.26
AL050337.1-0.41-0.26
APOC1-0.40-0.29
AL353354.3-0.38-0.13
GNG11-0.38-0.25
AL022328.1-0.38-0.34
C16orf74-0.38-0.30
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005005transmembrane-ephrin receptor activityTAS9126477 
GO:0046875ephrin receptor bindingIDA8808709 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016198axon choice point recognitionIEAneuron, axon (GO term level: 14)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9126477 
GO:0007267cell-cell signalingTAS9126477 
GO:0007628adult walking behaviorIEA-
GO:0048013ephrin receptor signaling pathwayIDA8808709 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS9126477 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPHA4HEK8 | SEK | TYRO1EPH receptor A4-HPRD,BioGRID9484836 |12383247 
EPHB3ETK2 | HEK2 | TYRO6EPH receptor B3-HPRD,BioGRID9484836 
GRIP2-glutamate receptor interacting protein 2in vitro
in vivo
Two-hybrid		BioGRID10197531 
RHBDL2MGC16997 | RRP2rhomboid, veinlet-like 2 (Drosophila)-HPRD,BioGRID15047175 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP 3024All SZGR genes in this pathway
MANTOVANI_NFKB_TARGETS_DN 116All SZGR genes in this pathway
MANTOVANI_VIRAL_GPCR_SIGNALING_DN 4937All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FGF3 87All SZGR genes in this pathway
GEISS_RESPONSE_TO_DSRNA_DN 168All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
PAL_PRMT5_TARGETS_DN 2916All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506921927m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-13815741580m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-1459139201A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-192/215160516111Ahsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-204/211173717441A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2816391645m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-34/449119912051Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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