Gene Page: EGR1

Summary
GeneID  1958
Symbol  EGR1
Synonyms  AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225
Description  early growth response 1
See related  HGNC:3238|MIM:128990|Ensembl:ENSG00000120738|HPRD:00549|
Locus tag  -
Gene type  protein-coding
Map location  5q31.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PGD0.970.96
TUBB0.970.96
EIF3L0.970.95
IP6K20.960.96
PRPSAP20.960.95
TRAFD10.960.90
RBM40.960.96
SMARCB10.960.94
ILF20.960.95
C4orf140.960.95
Top 10 negatively co-expressed genes
HLA-F-0.76-0.81
AIFM3-0.76-0.81
C5orf53-0.76-0.78
AF347015.27-0.75-0.91
AF347015.33-0.74-0.91
AF347015.31-0.74-0.88
MT-CO2-0.73-0.89
HEPN1-0.73-0.78
S100B-0.72-0.83
ALDOC-0.72-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA12560508 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0030217T cell differentiationIEA-
GO:0045941positive regulation of transcriptionIDA12560508 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIDA14744935 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID12947119 
Egr1 interacts with c/EBP-beta. This interaction was modeled on a demonstrated interaction between mouse Egr1 and human c/EBP-beta.BIND12947119 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID9806899 
CBP interacts with Egr1 promoter.BIND15225550 
CBP promoter interacts with Egr1.BIND15225550 
EP300KAT3B | p300E1A binding protein p300p300 interacts with Egr1 promoter.BIND15225550 
-HPRD,BioGRID9806899 
p300 interacts with Egr1.BIND15225550 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)Two-hybridBioGRID12840049 
GADD45ADDIT1 | GADD45growth arrest and DNA-damage-inducible, alphaEgr-1 interacts with Gadd45a promoter.BIND15616591 
GADD45BDKFZp566B133 | GADD45BETA | MYD118growth arrest and DNA-damage-inducible, betaEgr-1 interacts with Gadd45b promoter.BIND15616591 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD11278640 
NAB1-NGFI-A binding protein 1 (EGR1 binding protein 1)-HPRD,BioGRID7624335 
NAB2MADER | MGC75085NGFI-A binding protein 2 (EGR1 binding protein 2)-HPRD,BioGRID8668170 
NFATC1MGC138448 | NF-ATC | NFAT2 | NFATcnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1Reconstituted ComplexBioGRID12560487 
NFATC2KIAA0611 | NFAT1 | NFATPnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2-HPRD12560487 
PITX1BFT | POTX | PTX1paired-like homeodomain 1-HPRD,BioGRID10082522 
PSMA3HC8 | MGC12306 | MGC32631 | PSC3proteasome (prosome, macropain) subunit, alpha type, 3Reconstituted Complex
Two-hybrid		BioGRID12379479 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID10671503 
RelA interacts with Egr-1 promoter.BIND15616591 
SP1-Sp1 transcription factorEgr1 interacts with Sp1.This interaction was modelled on a demonstrated interaction between human Egr1 and mouse Sp1.BIND12569082 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11251186 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY 1111All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY 3631All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 6450All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_EARLY_UP 2119All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP 13085All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
YEMELYANOV_GR_TARGETS_DN 108All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
CHASSOT_SKIN_WOUND 109All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
RODRIGUES_NTN1_AND_DCC_TARGETS 3525All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN 2518All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_DN 1913All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
KORKOLA_TERATOMA 3925All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
BORLAK_LIVER_CANCER_EGF_UP 5741All SZGR genes in this pathway
WIEMANN_TELOMERE_SHORTENING_AND_CHRONIC_LIVER_DAMAGE_DN 65All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND 6940All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
FRIDMAN_SENESCENCE_DN 136All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_HELA 4229All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_MCF10A 1911All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_MCF10A 3924All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_40_MCF10A 3221All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_60_MCF10A 5742All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP 197110All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
LU_IL4_SIGNALING 9456All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN 2113All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
CHUANG_OXIDATIVE_STRESS_RESPONSE_UP 2818All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
SARTIPY_NORMAL_AT_INSULIN_RESISTANCE_UP 3427All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
WENG_POR_TARGETS_GLOBAL_DN 2314All SZGR genes in this pathway
ZHU_CMV_24_HR_UP 9365All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR 2013All SZGR genes in this pathway
ABE_VEGFA_TARGETS_30MIN 2921All SZGR genes in this pathway
ZHU_CMV_8_HR_UP 4739All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
JEPSEN_SMRT_TARGETS 3323All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION 1513All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP 2414All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
MATZUK_CENTRAL_FOR_FEMALE_FERTILITY 2925All SZGR genes in this pathway
MATZUK_LUTEAL_GENES 85All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_6HR_UP 108All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
LIN_NPAS4_TARGETS_DN 6848All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
TSAI_RESPONSE_TO_RADIATION_THERAPY 3220All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP 8550All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN 3726All SZGR genes in this pathway
TIAN_TNF_SIGNALING_NOT_VIA_NFKB 2216All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_1HR_DN 108All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_UP 3930All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC1 2312All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 4633All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN 7252All SZGR genes in this pathway
LIU_IL13_PRIMING_MODEL 1511All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
HOLLEMAN_DAUNORUBICIN_B_ALL_UP 109All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
ZWANG_CLASS_2_TRANSIENTLY_INDUCED_BY_EGF 5129All SZGR genes in this pathway
HECKER_IFNB1_TARGETS 9554All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.18388441Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506769775m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1819249301Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-183411417m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1916366431A,m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-203.12902961Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-234464521Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-3p9829891A,m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-377777783m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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