SZGR2

Summary ?

GeneID	2045
Symbol	EPHA7
Synonyms	EHK-3\|EHK3\|EK11\|HEK11
Description	EPH receptor A7
Reference	MIM:602190\|HGNC:HGNC:3390\|Ensembl:ENSG00000135333\|HPRD:03721\|Vega:OTTHUMG00000015228
Gene type	protein-coding
Map location	6q16.1
Pascal p-value	0.004

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NAPG	0.94	0.94
MAPK9	0.94	0.93
ATP6V1C1	0.93	0.93
B4GALT6	0.92	0.93
IDH3A	0.91	0.92
GLS	0.91	0.94
GLRB	0.91	0.92
SYT1	0.91	0.90
MOAP1	0.91	0.92
MAP2K4	0.90	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.49	-0.56
EFEMP2	-0.47	-0.48
NME4	-0.45	-0.57
CLEC3B	-0.45	-0.52
AL022328.1	-0.45	-0.48
RAB34	-0.44	-0.48
AC006276.2	-0.43	-0.43
IRF7	-0.42	-0.53
SIGIRR	-0.42	-0.49
AP003068.3	-0.41	-0.40

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004872	receptor activity	IEA		-
GO:0005003	ephrin receptor activity	IEA		-
GO:0005515	protein binding	ISS		-
GO:0005524	ATP binding	IEA		-
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN	291	176	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP	238	135	All SZGR 2.0 genes in this pathway
DAWSON METHYLATED IN LYMPHOMA TCL1	59	45	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP	36	27	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN	138	92	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP	169	105	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4	110	66	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP	54	38	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	73	79	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	73	79	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-133	1733	1739	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	1733	1739	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-134	1940	1946	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-137	1316	1323	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-137	1316	1323	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-141/200a	1818	1825	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1818	1825	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-142-5p	1335	1341	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497	74	81	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	776	782	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	1352	1358	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	671	677	m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-196	237	243	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	237	243	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-199	508	514	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	508	514	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-203.1	1612	1618	m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-204/211	177	184	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	177	184	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-26	144	150	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	144	150	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-3p	1723	1729	m8	hsa-miR-299-3p	UAUGUGGGAUGGUAAACCGCUU
miR-30-3p	242	248	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	242	248	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-378*	1031	1037	1A	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	1031	1037	1A	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-433-3p	347	353	m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-433-3p	347	353	m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-493-5p	304	310	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-503	75	81	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-539	1614	1620	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-9	1430	1436	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-9	1430	1436	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EPHA7