Gene Page: F2

Summary ?
GeneID2147
SymbolF2
SynonymsPT|RPRGL2|THPH1
Descriptioncoagulation factor II, thrombin
ReferenceMIM:176930|HGNC:HGNC:3535|Ensembl:ENSG00000180210|HPRD:01488|Vega:OTTHUMG00000150344
Gene typeprotein-coding
Map location11p11
Pascal p-value8.276E-8
eGeneCerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LYVE10.820.84
SIGLEC10.810.78
LILRB50.790.79
CD1630.780.85
DAB20.780.70
SLC6A200.740.70
CD2090.730.76
MPEG10.720.62
CYP1B10.700.85
KIAA11990.690.79
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SNHG12-0.34-0.48
RPS27A-0.32-0.56
RPS21-0.32-0.54
RPL23A-0.32-0.53
RPL37-0.32-0.55
NME4-0.31-0.46
RPL34-0.31-0.55
RPL31-0.30-0.51
RPS20-0.30-0.54
RPS15A-0.30-0.51

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)12855810 
GO:0004252serine-type endopeptidase activityIDAglutamate (GO term level: 7)12855810 
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisTAS7507931 
GO:0007262STAT protein nuclear translocationTAS10692450 
GO:0007260tyrosine phosphorylation of STAT proteinTAS10692450 
GO:0007166cell surface receptor linked signal transductionIDA1672265 
GO:0030168platelet activationTAS12855810 
GO:0009611response to woundingTAS12855810 
GO:0006953acute-phase responseIEA-
GO:0006919caspase activationTAS10692450 
GO:0006915apoptosisTAS10692450 
GO:0007275multicellular organismal developmentTAS9639571 
GO:0030194positive regulation of blood coagulationIDA9038223 
GO:0042730fibrinolysisIDA12855810 
GO:0051209release of sequestered calcium ion into cytosolIDA1672265 
GO:0032967positive regulation of collagen biosynthetic processIDA9639571 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2538457 |2742826 |2866798 
|12907439 |14982929 
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceTAS3242619 
GO:0005625soluble fractionTAS2719946 
GO:0005886plasma membraneEXP2538457 |12907439 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C6-complement component 6-HPRD3192535 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)Reconstituted ComplexBioGRID8663147 
F11FXI | MGC141891coagulation factor XI-HPRD1652157 
F2RCF2R | HTR | PAR1 | TRcoagulation factor II (thrombin) receptorThrombin interacts with PAR1. This interaction was modeled on a demonstrated interaction between Thrombin from an unspecified species and human PAR1.BIND15707890 
F2RL2PAR3coagulation factor II (thrombin) receptor-like 2-HPRD12732212 
F2RL3PAR4coagulation factor II (thrombin) receptor-like 3-HPRD12732212 
F5FVL | PCCFcoagulation factor V (proaccelerin, labile factor)-HPRD,BioGRID9032460 
F9FIX | HEMB | MGC129641 | MGC129642 | PTCcoagulation factor IX-HPRD15039440 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID1587268 |2133223 
GP1BABSS | CD42B | CD42b-alpha | GP1B | MGC34595glycoprotein Ib (platelet), alpha polypeptide-HPRD2933256 
ITGA2BCD41 | CD41B | GP2B | GPIIb | GTA | HPA3integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)-HPRD,BioGRID11487023 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD9864377 
KNG1BDK | KNGkininogen 1-HPRD1652157 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissueCo-crystal StructureBioGRID10543954 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD12878585 
SERPINB6CAP | DKFZp686I04222 | MGC111370 | MSTP057 | PI6 | PTI | SPI3serpin peptidase inhibitor, clade B (ovalbumin), member 6Reconstituted ComplexBioGRID8415716 
SERPINB8CAP2 | PI8serpin peptidase inhibitor, clade B (ovalbumin), member 8-HPRD9402754 
SERPINC1AT3 | ATIII | MGC22579serpin peptidase inhibitor, clade C (antithrombin), member 1-HPRD3800906 |11927130 
SERPIND1D22S673 | HC2 | HCF2 | HCII | HLS2 | LS2serpin peptidase inhibitor, clade D (heparin cofactor), member 1Co-crystal StructureBioGRID12169660 
SERPIND1D22S673 | HC2 | HCF2 | HCII | HLS2 | LS2serpin peptidase inhibitor, clade D (heparin cofactor), member 1-HPRD2760054 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Reconstituted ComplexBioGRID12709053 
SERPING1C1IN | C1INH | C1NH | HAE1 | HAE2serpin peptidase inhibitor, clade G (C1 inhibitor), member 1-HPRD,BioGRID11460008 
THBDCD141 | THRM | TMthrombomodulin-HPRD7615164 |8663147 
THBDCD141 | THRM | TMthrombomodulinReconstituted ComplexBioGRID2544585 |8663147 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID2435757 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY 2013All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY 2218All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 4535All SZGR 2.0 genes in this pathway
BIOCARTA EXTRINSIC PATHWAY 139All SZGR 2.0 genes in this pathway
BIOCARTA FIBRINOLYSIS PATHWAY 128All SZGR 2.0 genes in this pathway
BIOCARTA INTRINSIC PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA PLATELETAPP PATHWAY 1410All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 3728All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 2316All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID HNF3B PATHWAY 4537All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY 1511All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY 3225All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 2717All SZGR 2.0 genes in this pathway
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS 118All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME COMMON PATHWAY 1410All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 1612All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 3222All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 3220All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188116All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION 3623All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY 1712All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 DN 3822All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway