Gene Page: F2

Summary
GeneID  2147
Symbol  F2
Synonyms  PT
Description  coagulation factor II (thrombin)
See related  HGNC:3535|MIM:176930|Ensembl:ENSG00000180210|HPRD:01488|
Locus tag  -
Gene type  protein-coding
Map location  11p11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LYVE10.820.84
SIGLEC10.810.78
LILRB50.790.79
CD1630.780.85
DAB20.780.70
SLC6A200.740.70
CD2090.730.76
MPEG10.720.62
CYP1B10.700.85
KIAA11990.690.79
Top 10 negatively co-expressed genes
SNHG12-0.34-0.48
RPS27A-0.32-0.56
RPS21-0.32-0.54
RPL23A-0.32-0.53
RPL37-0.32-0.55
NME4-0.31-0.46
RPL34-0.31-0.55
RPL31-0.30-0.51
RPS20-0.30-0.54
RPS15A-0.30-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)12855810 
GO:0004252serine-type endopeptidase activityIDAglutamate (GO term level: 7)12855810 
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisTAS7507931 
GO:0007262STAT protein nuclear translocationTAS10692450 
GO:0007260tyrosine phosphorylation of STAT proteinTAS10692450 
GO:0007166cell surface receptor linked signal transductionIDA1672265 
GO:0030168platelet activationTAS12855810 
GO:0009611response to woundingTAS12855810 
GO:0006953acute-phase responseIEA-
GO:0006919caspase activationTAS10692450 
GO:0006915apoptosisTAS10692450 
GO:0007275multicellular organismal developmentTAS9639571 
GO:0030194positive regulation of blood coagulationIDA9038223 
GO:0042730fibrinolysisIDA12855810 
GO:0051209release of sequestered calcium ion into cytosolIDA1672265 
GO:0032967positive regulation of collagen biosynthetic processIDA9639571 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2538457 |2742826 |2866798 
|12907439 |14982929 
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceTAS3242619 
GO:0005625soluble fractionTAS2719946 
GO:0005886plasma membraneEXP2538457 |12907439 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C6-complement component 6-HPRD3192535 
CPB2CPU | PCPB | TAFIcarboxypeptidase B2 (plasma)Reconstituted ComplexBioGRID8663147 
F11FXI | MGC141891coagulation factor XI-HPRD1652157 
F2RCF2R | HTR | PAR1 | TRcoagulation factor II (thrombin) receptorThrombin interacts with PAR1. This interaction was modeled on a demonstrated interaction between Thrombin from an unspecified species and human PAR1.BIND15707890 
F2RL2PAR3coagulation factor II (thrombin) receptor-like 2-HPRD12732212 
F2RL3PAR4coagulation factor II (thrombin) receptor-like 3-HPRD12732212 
F5FVL | PCCFcoagulation factor V (proaccelerin, labile factor)-HPRD,BioGRID9032460 
F9FIX | HEMB | MGC129641 | MGC129642 | PTCcoagulation factor IX-HPRD15039440 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID1587268 |2133223 
GP1BABSS | CD42B | CD42b-alpha | GP1B | MGC34595glycoprotein Ib (platelet), alpha polypeptide-HPRD2933256 
ITGA2BCD41 | CD41B | GP2B | GPIIb | GTA | HPA3integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)-HPRD,BioGRID11487023 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD9864377 
KNG1BDK | KNGkininogen 1-HPRD1652157 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissueCo-crystal StructureBioGRID10543954 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD12878585 
SERPINB6CAP | DKFZp686I04222 | MGC111370 | MSTP057 | PI6 | PTI | SPI3serpin peptidase inhibitor, clade B (ovalbumin), member 6Reconstituted ComplexBioGRID8415716 
SERPINB8CAP2 | PI8serpin peptidase inhibitor, clade B (ovalbumin), member 8-HPRD9402754 
SERPINC1AT3 | ATIII | MGC22579serpin peptidase inhibitor, clade C (antithrombin), member 1-HPRD3800906 |11927130 
SERPIND1D22S673 | HC2 | HCF2 | HCII | HLS2 | LS2serpin peptidase inhibitor, clade D (heparin cofactor), member 1Co-crystal StructureBioGRID12169660 
-HPRD2760054 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Reconstituted ComplexBioGRID12709053 
SERPING1C1IN | C1INH | C1NH | HAE1 | HAE2serpin peptidase inhibitor, clade G (C1 inhibitor), member 1-HPRD,BioGRID11460008 
THBDCD141 | THRM | TMthrombomodulin-HPRD7615164 |8663147 
Reconstituted ComplexBioGRID2544585 |8663147 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID2435757 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_AMI_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_EXTRINSIC_PATHWAY 139All SZGR genes in this pathway
BIOCARTA_FIBRINOLYSIS_PATHWAY 128All SZGR genes in this pathway
BIOCARTA_INTRINSIC_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_PLATELETAPP_PATHWAY 1410All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
PID_THROMBIN_PAR4_PATHWAY 1511All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY 3225All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION 2717All SZGR genes in this pathway
REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS 118All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_COMMON_PATHWAY 1410All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS 1612All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE 3222All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 188116All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY 1712All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_DN 3822All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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