Gene Page: KDM1A

Summary ?
GeneID23028
SymbolKDM1A
SynonymsAOF2|BHC110|CPRF|KDM1|LSD1
Descriptionlysine demethylase 1A
ReferenceMIM:609132|HGNC:HGNC:29079|Ensembl:ENSG00000004487|HPRD:09800|Vega:OTTHUMG00000003220
Gene typeprotein-coding
Map location1p36.12
Pascal p-value0.465
Sherlock p-value0.317
Fetal beta1.795
eGeneMyers' cis & trans
SupportAscano FMRP targets
Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4854166chr23297005KDM1A230280.18trans
rs6902183chr6121963786KDM1A230280.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AOF2BHC110 | KDM1 | KIAA0601 | LSD1amine oxidase (flavin containing) domain 2Affinity Capture-MSBioGRID12493763 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Two-hybridBioGRID16169070 
ATP5J2ATP5JLATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2Two-hybridBioGRID16169070 
CCDC90BMDS011 | MDS025 | MGC104239coiled-coil domain containing 90BTwo-hybridBioGRID16169070 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, iAffinity Capture-MS
Affinity Capture-Western		BioGRID12493763 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID12493763 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID9804427 |12032298 
|12493763 
HIST3H3H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888histone cluster 3, H3LSD1 interacts with and demethylates H3.BIND15620353 
HMG20BBRAF25 | BRAF35 | FLJ26127 | HMGX2 | PP7706 | SMARCE1r | SOXL | pp8857high-mobility group 20BAffinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID12032298 |12493763 
IMMTDKFZp779P1653 | HMP | MGC111146 | P87 | P87/89 | P89 | PIG4 | PIG52inner membrane protein, mitochondrial (mitofilin)Two-hybridBioGRID16169070 
KIAA0182GSE1KIAA0182Affinity Capture-MSBioGRID12493763 
PHF21ABHC80 | BM-006 | KIAA1696PHD finger protein 21A-HPRD,BioGRID15325272 
RCOR1COREST | KIAA0071 | RCORREST corepressor 1Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID11171972 |12032298 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1Two-hybridBioGRID16169070 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-WesternBioGRID11171972 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
ZMYM2FIM | MYM | RAMP | SCLL | ZNF198zinc finger, MYM-type 2Affinity Capture-MSBioGRID12493763 
ZMYM3DXS6673E | KIAA0385 | MYM | XFIM | ZNF198L2 | ZNF261zinc finger, MYM-type 3Affinity Capture-MSBioGRID12493763 
ZNF217ZABC1zinc finger protein 217Affinity Capture-MSBioGRID12493763 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID AR PATHWAY 6146All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 10068All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187122All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER HEREDITARY VS SPORADIC 5032All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway