SZGR2

Summary ?

GeneID	23122
Symbol	CLASP2
Synonyms	-
Description	cytoplasmic linker associated protein 2
Reference	MIM:605853\|HGNC:HGNC:17078\|Ensembl:ENSG00000163539\|HPRD:12054\|Vega:OTTHUMG00000156489
Gene type	protein-coding
Map location	3p22.3
Pascal p-value	0.01
Sherlock p-value	0.525
eGene	Myers' cis & trans
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0261

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs736718	chr16	82656424	CLASP2	23122		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MTOR	0.94	0.95
MYH10	0.92	0.93
CLCN6	0.92	0.92
UBE2O	0.92	0.93
LARP4B	0.92	0.92
EIF4G3	0.91	0.92
HERC2	0.91	0.92
VPS53	0.91	0.91
ATRN	0.91	0.93
ADAR	0.91	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.71	-0.70
HIGD1B	-0.70	-0.72
AF347015.21	-0.69	-0.73
C1orf54	-0.69	-0.79
MT-CO2	-0.68	-0.68
FXYD1	-0.68	-0.66
GNG11	-0.66	-0.70
VAMP5	-0.66	-0.68
AC021016.1	-0.65	-0.65
S100A16	-0.65	-0.66

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		11290329
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	NAS		11290329
GO:0008017	microtubule binding	IEA		-
GO:0051010	microtubule plus-end binding	IDA		11290329
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007026	negative regulation of microtubule depolymerization	IEA		-
GO:0007026	negative regulation of microtubule depolymerization	NAS		11290329
GO:0007163	establishment or maintenance of cell polarity	TAS		15928712
GO:0007049	cell cycle	IEA		-
GO:0007067	mitosis	IEA		-
GO:0051301	cell division	IEA		-
GO:0031110	regulation of microtubule polymerization or depolymerization	IMP		11290329
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000777	condensed chromosome kinetochore	IEA		-
GO:0005794	Golgi apparatus	IDA		11290329
GO:0005794	Golgi apparatus	IEA		-
GO:0005813	centrosome	IEA		-
GO:0005819	spindle	IEA		-
GO:0005828	kinetochore microtubule	TAS		12837247
GO:0005856	cytoskeleton	IEA		-
GO:0005881	cytoplasmic microtubule	IDA		11290329
GO:0005881	cytoplasmic microtubule	IEA		-
GO:0005737	cytoplasm	NAS		11290329

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
SILIGAN TARGETS OF EWS FLI1 FUSION DN	18	9	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER DN	24	15	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN	150	93	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS	212	121	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS	78	49	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION	130	87	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1078	1084	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-138	948	954	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	306	313	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	306	313	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-18	952	958	m8	hsa-miR-18a	UAAGGUGCAUCUAGUGCAGAUA
miR-18	952	958	m8	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
miR-200bc/429	215	222	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	265	271	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-26	1625	1632	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1625	1632	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-31	656	663	1A,m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-320	360	366	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-338	335	341	m8	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-381	317	323	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-496	174	180	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	174	180	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-539	1284	1291	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-539	1284	1291	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-544	406	412	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-7	286	292	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CLASP2